Evidence map›Paper›PMID 36143203›Full record

ArticleJournal of personalized medicine2022

DNA Directed Pro-Dopamine Regulation Coupling Subluxation Repair, H-Wave

Anish Bajaj, Kenneth Blum, Abdalla Bowirrat, Ashim Gupta, David Baron, David Fugel, Ayo Nicholson, Taylor Fitch, B William Downs, Debasis Bagchi and 2 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. A Comprehensive 4-layeredCurrent pharmaceutical biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Anish BajajBajaj Chiropractic Clinic, New York, NY 10010, USA.ORCID 0000-0002-7079-6740
Kenneth BlumDivision of Addiction Research & Education, Center for Psychiatry, Medicine, and Primary Care, (Office of the Provost), Western University Health Sciences, Pomona, CA 91766, USA.ORCID 0000-0001-6727-803X
Abdalla BowirratDepartment of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel 40700, Israel.ORCID 0000-0001-8185-0688
Ashim GuptaFuture Biologics, Lawrenceville, GA 30043, USA.ORCID 0000-0003-1224-2755
David BaronDivision of Addiction Research & Education, Center for Psychiatry, Medicine, and Primary Care, (Office of the Provost), Western University Health Sciences, Pomona, CA 91766, USA.
David FugelBajaj Chiropractic Clinic, New York, NY 10010, USA.
Ayo NicholsonBajaj Chiropractic Clinic, New York, NY 10010, USA.
Taylor FitchBajaj Chiropractic Clinic, New York, NY 10010, USA.
B William DownsDepartment of Psychiatry, South Texas Veteran Health Care System, Audie L. Murphy Memorial VA Hospital, Long School of Medicine, University of Texas Medical Center, San Antonio, TX 78229, USA.ORCID 0000-0003-2096-8265
Debasis BagchiDepartment of Pharmaceutical Sciences, Southern University College of Pharmacy, Houston, TX 77004, USA.ORCID 0000-0001-9478-6427
Catherine A DennenThe Kenneth Blum Institute on Behavior & Neurogenetics, Austin, TX 78701, USA.
Rajendra D BadgaiyanDepartment of Psychiatry, South Texas Veteran Health Care System, Audie L. Murphy Memorial VA Hospital, Long School of Medicine, University of Texas Medical Center, San Antonio, TX 78229, USA.ORCID 0000-0001-5586-5114
Texas Medical Center · USWestern University of Health Sciences · USAriel University · ILTexas Southern University · US

Funding

A Systematic Medical Approach to Reward Transformation (SMART) for Brain Health in Opioid Use DisorderR41MD012318 · NIMHD · VERSA INTEGRATED SOLUTIONS, INC. · PI BLUM, KENNETH, GONDRE-LEWIS, MARJORIE C · 2017 to 2017
$221k
Dopamine neurotransmission in Gulf War Veteran's IllnessI01CX002099 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI BADGAIYAN, RAJENDRA D · 2021 to 2021
–
CSRD VA I01 CX002099NIMHD NIH HHS R41 MD012318This research was funded by Electronic Waveform Lab Inc., Huntington Beach, CA, USA. K.B. and M.C.G. are recipients of R41 MD012318/MD/NIMHD NIH HHS/United States. 1101 CX002099-01 (PI: R.D.B.) Merit review grant, Veterans Administration. NA
6 · The paper itself

Abstract

Addiction is a complex multifactorial condition. Established genetic factors can provide clear guidance in assessing the risk of addiction to substances and behaviors. Chronic stress can accumulate, forming difficult to recognize addiction patterns from both genetic and epigenetic (environmental) factors. Furthermore, psychological/physical/chemical stressors are typically categorized linearly, delaying identification and treatment. The patient in this case report is a Caucasian female, aged 36, who presented with chronic pain and partial disability following a surgically repaired trimalleolar fracture. The patient had a history of unresolved attention deficit disorder and an MRI scan of her brain revealed atrophy and functional asymmetry. In 2018, the patient entered the Bajaj Chiropractic Clinic, where initial treatment focused on re-establishing integrity of the spine and lower extremity biomechanics and graduated into cognitive behavior stabilization assisted by DNA pro-dopamine regulation guided by Genetic Addiction Risk Severity testing. During treatment (2018-2021), progress achieved included: improved cognitive clarity, focus, sleep, anxiety, and emotional stability in addition to pain reduction (75%); elimination of powerful analgesics; and reduced intake of previously unaddressed alcoholism. To help reduce hedonic addictive behaviors and pain, coupling of H-Wave with corrective chiropractic care seems prudent. We emphasize the importance of genetic assessment along with attempts at inducing required dopaminergic homeostasis via precision KB220PAM. It is hypothesized that from preventive care models, a new standard is emerging including self-awareness and accountability for reward deficiency as a function of hypodopaminergia. This case study documents the progression of a patient dealing with the complexities of an injury, pain management, cognitive impairment, anxiety, depression, and the application of universal health principles towards correction versus palliative care.

Indexed as

cognitive behavioral therapydopamineGenetic Addiction Risk Severity (GARS)H-WaveKB220PAMphotobiomodulationproprioceptionresting state networkReward Deficiency Syndrome (RDS)subluxation

Identifiers

PMID36143203
PMCPMC9503998
OpenAlexW4293773334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.