ArticleJournal of personalized medicine2022
Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05526352 (@neurIST), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
@neurIST : Informatique biomédicale intégrée Pour la Gestion Des anévrismes cérébraux
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Risk of subarachnoid haemorrhage reduces with blood pressure values below hypertensive thresholds.European journal of neurology · 2024Pooled it
- Endovascular treatment of unruptured intracranial aneurysms at a single center: Outcomes, selection strategy, and transparent communication for patient decision-making.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Higher Incidence of Unruptured Intracranial Aneurysms among Black and Hispanic Women on Screening MRA in Large Urban Populations.AJNR. American journal of neuroradiology · 2023Article
- Lower incidence of diabetes mellitus in patients with aneurysmal subarachnoid hemorrhage: a large case-control study with propensity score matching.Frontiers in neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
62 authors at 20 institutions in 10 countries.
Sandrine MorelNeurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.ORCID 0000-0003-1538-3553
Isabel C HostettlerStroke Research Centre, University College London Queen Square Institute of Neurology, London WC1N 3BG, UK.ORCID 0000-0002-9004-2540
Georg R SpinnerZHAW School of Life Sciences and Facility Management, 8820 Wädenswil, Switzerland.
Romain BourcierInstitut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), University Hospital Centre Nantes, University of Nantes, L'institut Du Thorax, 44007 Nantes, France.
Joanna PeraDepartment of Neurology, Faculty of Medicine, Jagiellonian University Medical College, ul. Botaniczna 3, 31-503 Krakow, Poland.ORCID 0000-0001-6142-2969
Torstein R MelingNeurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.ORCID 0000-0001-6595-0873
Varinder S AlgStroke Research Centre, University College London Queen Square Institute of Neurology, London WC1N 3BG, UK.
Henry HouldenNeurogenetics Laboratory, The National Hospital of Neurology and Neurosurgery, London WC1N 3BG, UK.
Mark K BakkerDepartment of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, 3584 CS Utrecht, The Netherlands.ORCID 0000-0002-7887-9014
Femke Van't HofDepartment of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, 3584 CS Utrecht, The Netherlands.
Gabriel J E RinkelDepartment of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, 3584 CS Utrecht, The Netherlands.
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Dongbing LaiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-7803-580X
Charles J MoomawDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Bradford B WorrallDepartments of Neurology and Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Jildaz CaroffDepartment of Interventional Neuroradiology-NEURI Brain Vascular Center, Bicêtre Hospital, APHP, 94270 Le Kremlin Bicêtre, France.
Pacôme Constant-Dits-BeaufilsInstitut national de la santé et de la recherche médicale (INSERM), CIC 1413, Clinique des Données, University Hospital Centre Nantes, 44000 Nantes, France.
Matilde KarakachoffInstitut national de la santé et de la recherche médicale (INSERM), CIC 1413, Clinique des Données, University Hospital Centre Nantes, 44000 Nantes, France.
Antoine RimbertInstitut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), University Hospital Centre Nantes, University of Nantes, L'institut Du Thorax, 44007 Nantes, France.
Aymeric RouchaudDepartment of Neuroradiology, Dupuytren University Hospital, 87000 Limoges, France.
Emilia I Gaal-PaavolaDepartment of Neurosurgery, Helsinki University Hospital, University of Helsinki, 00260 Helsinki, Finland.
Hanna KaukovaltaDepartment of Neurosurgery, Helsinki University Hospital, University of Helsinki, 00260 Helsinki, Finland.
Riku KivisaariDepartment of Neurosurgery, Helsinki University Hospital, University of Helsinki, 00260 Helsinki, Finland.
Aki LaaksoDepartment of Neurosurgery, Helsinki University Hospital, University of Helsinki, 00260 Helsinki, Finland.
Behnam Rezai JahromiDepartment of Neurosurgery, Helsinki University Hospital, University of Helsinki, 00260 Helsinki, Finland.ORCID 0000-0003-3937-2816
Riikka TulamoNeurosurgery Research Group, Biomedicum, 00290 Helsinki, Finland.
Christoph M FriedrichDepartment of Computer Science, University of Applied Science and Arts, 44139 Dortmund, Germany.ORCID 0000-0001-7906-0038
Jerome DauvillierSIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Sven HirschZHAW School of Life Sciences and Facility Management, 8820 Wädenswil, Switzerland.ORCID 0000-0002-5678-4110
Nathalie IsidorNeurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.
Zolt KulcsàrDiagnostic and Interventional, Department of Diagnostics, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.
Karl O LövbladDiagnostic and Interventional, Department of Diagnostics, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.
Olivier MartinSIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Paolo MachiDiagnostic and Interventional, Department of Diagnostics, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.
Vitor Mendes PereiraDivision of Neurosurgery, Department of Surgery, St Michael's Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada.
Daniel RüfenachtSwiss Neuroradiology Institute, 8002 Zurich, Switzerland.
Karl SchallerNeurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.
Sabine SchillingZHAW School of Life Sciences and Facility Management, 8820 Wädenswil, Switzerland.
Agnieszka SlowikDepartment of Neurology, Faculty of Medicine, Jagiellonian University Medical College, ul. Botaniczna 3, 31-503 Krakow, Poland.
Juha E JaaskelainenNeurosurgery NeuroCenter Kuopio, University Hospital Kuopio, 70210 Kuopio, Finland.
Mikael von Und Zu FraunbergNeurosurgery NeuroCenter Kuopio, University Hospital Kuopio, 70210 Kuopio, Finland.
Jordi Jiménez-CondeInstitut Hospital del Mar d'Investigacions Biomèdiques (IMIM) and Hospital del Mar, 08003 Barcelona, Spain.
Elisa Cuadrado-GodiaInstitut Hospital del Mar d'Investigacions Biomèdiques (IMIM) and Hospital del Mar, 08003 Barcelona, Spain.ORCID 0000-0002-9147-875X
Carolina Soriano-TárragaInstitut Hospital del Mar d'Investigacions Biomèdiques (IMIM) and Hospital del Mar, 08003 Barcelona, Spain.
Iona Y MillwoodClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX1 2JD, UK.
Robin G WaltersClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX1 2JD, UK.
The neurIST Project
The Ican Study Group
Genetics And Observational Subarachnoid Haemorrhage Gosh Study Investigators
International Stroke Genetics Consortium Isgc
Helen KimDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94143, USA.
Richard RedonInstitut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), University Hospital Centre Nantes, University of Nantes, L'institut Du Thorax, 44007 Nantes, France.
Nerissa U KoDepartment of Neurology, University of California, San Francisco, CA 94143, USA.
Guy A RouleauMontreal Neurological Institute and Hospital, McGill University, Montréal, QC H3A 0G4, Canada.
Antti LindgrenNeurosurgery NeuroCenter Kuopio, University Hospital Kuopio, 70210 Kuopio, Finland.
Mika NiemeläDepartment of Neurosurgery, Helsinki University Hospital, University of Helsinki, 00260 Helsinki, Finland.
Hubert DesalDepartment of Neuroradiology, University Hospital of Nantes, 44000 Nantes, France.
Daniel WooDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Joseph P BroderickDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
David J WerringStroke Research Centre, University College London Queen Square Institute of Neurology, London WC1N 3BG, UK.
Ynte M RuigrokDepartment of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, 3584 CS Utrecht, The Netherlands.
Philippe BijlengaNeurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.ORCID 0000-0002-3586-2757
University Hospital of Geneva · CHUniversity of Helsinki · FIUtrecht University · NLCentre National de la Recherche Scientifique · FRNational Hospital for Neurology and Neurosurgery · GBHospital del Mar Research Institute · ESUniversity of Eastern Finland · FIZHAW Zurich University of Applied Sciences · CHIndiana University School of MedicineInserm · FRJagiellonian University · PLMontreal Neurological Institute and Hospital · CASIB Swiss Institute of Bioinformatics · CHUniversity of California, San Francisco · USUniversity of Oxford · GBBicêtre Hospital · FRDortmund University of Applied Sciences and Arts · DEHôpital Dupuytren · FRSt. Michael's Hospital · CAUniversity of Cincinnati Medical Center · US
Funding
Agence Nationale de la Recherche ANR-15-CE17-0008-01CIHR naDutch Heart Foundation CVON2015-08 ERASEEuropean Commission FP6-IST-2004-027703European Research Council under the European Union's Horizon 2020 naGenavie Foundation naHelsinki University Central Hospital EVO TYH2018316innovation programme PRYSM 852173NIH Funding naSociété Française de Radiologie and the Société Française de Neuroradiologie naSpain's Ministry of Health Instituto de Salud Carlos III FEDERSpain's Ministry of Health RD16/0019/0002Spain's Ministry of Health RD16/0019/0010 INVICTUS-PLUSSwiss SystemsX.ch initiative naVaCaRMe program na
Abstract
Intracranial aneurysms (IAs) are usually asymptomatic with a low risk of rupture, but consequences of aneurysmal subarachnoid hemorrhage (aSAH) are severe. Identifying IAs at risk of rupture has important clinical and socio-economic consequences. The goal of this study was to assess the effect of patient and IA characteristics on the likelihood of IA being diagnosed incidentally versus ruptured. Patients were recruited at 21 international centers. Seven phenotypic patient characteristics and three IA characteristics were recorded. The analyzed cohort included 7992 patients. Multivariate analysis demonstrated that: (1) IA location is the strongest factor associated with IA rupture status at diagnosis; (2) Risk factor awareness (hypertension, smoking) increases the likelihood of being diagnosed with unruptured IA; (3) Patients with ruptured IAs in high-risk locations tend to be older, and their IAs are smaller; (4) Smokers with ruptured IAs tend to be younger, and their IAs are larger; (5) Female patients with ruptured IAs tend to be older, and their IAs are smaller; (6) IA size and age at rupture correlate. The assessment of associations regarding patient and IA characteristics with IA rupture allows us to refine IA disease models and provide data to develop risk instruments for clinicians to support personalized decision-making.
Indexed as
hypertensionintracranial aneurysmlocationrisk factorssmokingsubarachnoid hemorrhage
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT05526352ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.