Evidence map›Paper›PMID 36143168›Full record

ReviewJournal of personalized medicine2022

Pharmacogenetic Expression of CYP2C19 in a Pediatric Population.

Marie Josette Déborah Pierre-François, Vincent Gagné, Ivan Brukner, Maja Krajinovic

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. From genes to drugs:Frontiers in pharmacology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Marie Josette Déborah Pierre-FrançoisDepartment of Pharmacology and Physiology, University of Montréal, Montreal, QC H3C 3J7, Canada.ORCID 0000-0002-2176-5331
Vincent GagnéDepartment of Pediatrics, University of Montreal, Montreal, QC H3T 1C5, Canada.
Ivan BruknerLady Davies Research Institute, Montreal, QC H3T 1E2, Canada.ORCID 0000-0003-0225-9238
Maja KrajinovicDepartment of Pharmacology and Physiology, University of Montréal, Montreal, QC H3C 3J7, Canada.ORCID 0000-0003-4772-7031
Université de Montréal · CACentre Hospitalier Universitaire Sainte-Justine · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic variability in CYP2C19 may be associated with both lack of efficacy and toxicity of drugs due to its different metabolic status based on the presence of particular alleles. This literature review summarizes current knowledge relative to the association or treatment adaptation based on

Indexed as

anti-depressantsclopidogrelCYP2C19genotypingmetabolizerpediatricsproton pump inhibitorstrough plasma concentrationvoriconazole

Identifiers

PMID36143168
PMCPMC9504170
OpenAlexW4293758510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.