Evidence map›Paper›PMID 36143018›Full record

ArticleJournal of clinical medicine2022

Fluoride Exposure and Salivary Glands: How Is Glandular Morphology Susceptible to Long-Term Exposure? A Preclinical Study.

José Mário Matos-Sousa, Leonardo Oliveira Bittencourt, Maria Karolina Martins Ferreira, Vinicius Ruan Neves Dos Santos, Karolyny Martins Balbinot, Sérgio Alves-Júnior, João de Jesus Viana Pinheiro, Senda Charone, Juliano Pelim Pessan, Rafael Rodrigues Lima

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

José Mário Matos-SousaLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
Leonardo Oliveira BittencourtLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
Maria Karolina Martins FerreiraLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
Vinicius Ruan Neves Dos SantosLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.ORCID 0000-0001-7887-3811
Karolyny Martins BalbinotSchool of Dentistry, Federal University of Pará, Belém 66075-110, PA, Brazil.
Sérgio Alves-JúniorSchool of Dentistry, Federal University of Pará, Belém 66075-110, PA, Brazil.
João de Jesus Viana PinheiroSchool of Dentistry, Federal University of Pará, Belém 66075-110, PA, Brazil.ORCID 0000-0002-6914-6441
Senda CharoneLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
Juliano Pelim PessanDepartment of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University, Araçatuba 14801-385, SP, Brazil.ORCID 0000-0002-1550-3933
Rafael Rodrigues LimaLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.ORCID 0000-0003-1486-4013

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite a strong body of evidence attesting to the effectiveness of fluoride (F) in preventing and controlling caries, some studies have sought to investigate the influence of F exposure on the salivary glands, organs that are essential for the maintenance of cavity homeostasis through salivary production, finding that exposure to F can cause biochemical and proteomic changes. Thus, this study aimed to investigate the morphological effects of prolonged exposure to F on the salivary glands of mice, at concentrations that would correspond to optimally fluoridated water (suitable for human consumption) and to fluorosis-endemic regions. Twenty-four male mice (

Indexed as

fluoridesalivary glandssodium fluoride

Identifiers

PMID36143018
PMCPMC9501535

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.