Evidence map›Paper›PMID 36142992›Full record

ArticleJournal of clinical medicine2022

Outcomes of Pregnancies and Deliveries of Patients Who Underwent Fertility-Preserving Surgery for Early-Stage Epithelial Ovarian Cancer.

Shin Nishio, Takayo Takeno, Takeshi Fukuda, Ayumi Shikama, Hidekatsu Nakai, Hiroko Nakamura, Hideki Tokunaga, Kazuaki Takahashi, Emi Okuma, Masahiko Mori and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Pregnancy after advanced ovarian cancer with spontaneous uterine rupture in second trimester: A case report and review of the literature.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 1 country.

Shin NishioDepartment of Obstetrics and Gynecology, School of Medicine, Kurume University, Kurume 830-0011, Japan.ORCID 0000-0003-2526-630X
Takayo TakenoDepartment of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima 890-8760, Japan.
Takeshi FukudaDepartment of Obstetrics and Gynecology, School of Medicine, Osaka Metropolitan University, Osaka 545-8586, Japan.
Ayumi ShikamaDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8576, Japan.
Hidekatsu NakaiDepartment of Obstetrics and Gynecology, Faculty of Medicine, Kindai Universit, Sayama 589-8511, Japan.
Hiroko NakamuraDepartment of Obstetrics and Gynecology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Kure 737-0023, Japan.
Hideki TokunagaDepartment of Obstetrics and Gynecology, School of Medicine, Tohoku University, Sendai 980-8574, Japan.
Kazuaki TakahashiDepartment of Obstetrics and Gynecology, School of Medicine, The Jikei University, Tokyo 105-8471, Japan.ORCID 0000-0003-0419-1927
Emi OkumaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Saga University, Saga 849-8501, Japan.
Masahiko MoriDepartment of Gynecologic Oncology, Aichi Cancer Center Hospital, Nagoya 464-0021, Japan.
Yasuhisa TeraoDepartment of Obstetrics and Gynecology, Faculty of Medicine, Juntendo University, Tokyo 113-0033, Japan.
Kimio UshijimaDepartment of Obstetrics and Gynecology, School of Medicine, Kurume University, Kurume 830-0011, Japan.
Nobuo YaegashiDepartment of Obstetrics and Gynecology, School of Medicine, Tohoku University, Sendai 980-8574, Japan.
Kurume University · JPTohoku University · JPAichi Cancer Center · JPJikei University School of Medicine · JPJuntendo University · JPKagoshima City Hospital · JPKindai University · JPNational Hospital Organization · JPOsaka Metropolitan University · JPSaga University · JPUniversity of Tsukuba · JP

Funding

National Cancer Center Research and Development Fund of Japan 23-A-17, 26-A-4, 29-A-3
6 · The paper itself

Abstract

Some studies have shown increased risks of preterm birth, low birth weight, and cesarean delivery after oncologic treatment; others have shown the opposite. We evaluated the outcomes of pregnancies and deliveries of patients who underwent fertility-preserving surgery (FSS) for early-stage epithelial ovarian cancer (EOC) and examined their perinatal prognosis. This retrospective study included women with a history of stage IA or IC ovarian cancer reported in our previous study. The primary outcome was preterm birth after cancer diagnosis was considered. Secondary outcomes were neonatal morbidity and severe maternal morbidity. Thirty-one children were born to 25 women who had undergone FSS. The mean number of weeks at delivery was 38.7 ± 0.7, and the mean birth weight of infants was 3021 ± 160 g. With respect to pregnancy outcomes, 5 patients had preterm labor and 26 had full-term labor. The delivery mode was vaginal delivery in 18 patients and cesarean delivery in 13. Complications during pregnancy included placenta previa (one case) and pelvic abscess (one case). Except for three preterm infants with low birth weight, there were no other perinatal abnormalities. Pregnancy after fertility preservation in EOC has an excellent perinatal prognosis, although the cesarean delivery rate is high.

Indexed as

early-stage epithelial ovarian cancerfertility-preserving surgeryperinatal prognosispreterm birth

Identifiers

PMID36142992
PMCPMC9503365
OpenAlexW4295539697

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.