Evidence map›Paper›PMID 36142936›Full record

ArticleJournal of clinical medicine2022

Predicting Mortality Using Machine Learning Algorithms in Patients Who Require Renal Replacement Therapy in the Critical Care Unit.

Hsin-Hsiung Chang, Jung-Hsien Chiang, Chi-Shiang Wang, Ping-Fang Chiu, Khaled Abdel-Kader, Huiwen Chen, Edward D Siew, Jonathan Yabes, Raghavan Murugan, Gilles Clermont and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Hsin-Hsiung ChangDivision of Nephrology, Department of Internal Medicine, Antai Medical Care Corporation Antai Tian-Sheng Memorial Hospital, Donggang 928, Taiwan.ORCID 0000-0003-3180-5154
Jung-Hsien ChiangDepartment of Computer Science and Information Engineering, National Cheng Kung University, Tainan 701, Taiwan.
Chi-Shiang WangDepartment of Computer Science and Information Engineering, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0002-8707-279X
Ping-Fang ChiuDivision of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan.
Khaled Abdel-KaderDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37011, USA.
Huiwen ChenRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Edward D SiewDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN 37011, USA.
Jonathan YabesDivision of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Raghavan MuruganProgram for Critical Care Nephrology, CRISMA, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Gilles ClermontDepartment of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Paul M PalevskyRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-7334-5400
Manisha JhambRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
University of Pittsburgh · USNational Cheng Kung University · TWMingDao University · TWValley Health System · USVanderbilt University Medical Center · US

Funding

Vanderbilt O'Brien Kidney Center - Core D - Clinical and Translational CoreP30DK114809 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DE CAESTECKER, MARK P. · 2017 to 2021
$5.9M
AI driven acute renal replacement therapy - (AID-ART)R01DK131586 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLERMONT, GILLES, KASHANI, KIANOUSH B · 2021 to 2024
$2.5M
NIDDK NIH HHS P30 DK114809
6 · The paper itself

Abstract

Background: General severity of illness scores are not well calibrated to predict mortality among patients receiving renal replacement therapy (RRT) for acute kidney injury (AKI). We developed machine learning models to make mortality prediction and compared their performance to that of the Sequential Organ Failure Assessment (SOFA) and HEpatic failure, LactatE, NorepInephrine, medical Condition, and Creatinine (HELENICC) scores. Methods: We extracted routinely collected clinical data for AKI patients requiring RRT in the MIMIC and eICU databases. The development models were trained in 80% of the pooled dataset and tested in the rest of the pooled dataset. We compared the area under the receiver operating characteristic curves (AUCs) of four machine learning models (multilayer perceptron [MLP], logistic regression, XGBoost, and random forest [RF]) to that of the SOFA, nonrenal SOFA, and HELENICC scores and assessed calibration, sensitivity, specificity, positive (PPV) and negative (NPV) predicted values, and accuracy. Results: The mortality AUC of machine learning models was highest for XGBoost (0.823; 95% confidence interval [CI], 0.791−0.854) in the testing dataset, and it had the highest accuracy (0.758). The XGBoost model showed no evidence of lack of fit with the Hosmer−Lemeshow test (p > 0.05). Conclusion: XGBoost provided the highest performance of mortality prediction for patients with AKI requiring RRT compared with previous scoring systems.

Indexed as

acute kidney injurymachine learning algorithmmortalityrenal replacement therapy

Identifiers

PMID36142936
PMCPMC9500742
OpenAlexW4296111641

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.