Evidence map›Paper›PMID 36142926›Full record

ArticleJournal of clinical medicine2022

Efficacy and Safety of Tacrolimus as Treatment for Bleeding Caused by Hereditary Hemorrhagic Telangiectasia: An Open-Label, Pilot Study.

Josefien Hessels, Steven Kroon, Sanne Boerman, Rik C Nelissen, Jan C Grutters, Repke J Snijder, Franck Lebrin, Marco C Post, Christine L Mummery, Johannes-Jurgen Mager

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Hereditary haemorrhagic telangiectasia.Nature reviews. Disease primers · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Josefien HesselsDepartment of Pulmonology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands.ORCID 0000-0002-9001-9893
Steven KroonDepartment of Pulmonology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands.ORCID 0000-0003-1098-5555
Sanne BoermanDepartment of Pulmonology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands.
Rik C NelissenDepartment of Otorhinolaryngology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands.
Jan C GruttersDepartment of Pulmonology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands.
Repke J SnijderDepartment of Pulmonology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands.
Franck LebrinDepartment of Internal Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-1650-6757
Marco C PostDepartment of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3484 CX Utrecht, The Netherlands.
Christine L MummeryDepartment of Anatomy and Embryology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Johannes-Jurgen MagerDepartment of Pulmonology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands.
St. Antonius Ziekenhuis · NLHeidelberg University · DELeiden University Medical Center · NL

Funding

Association Maladie de Rendu-Osler (AMRO foundation) xKees Westermann Fund xNetherlands Organisation for Health Research and Development 446002501
6 · The paper itself

Abstract

Haploinsufficiency for Endoglin (ENG) and activin A receptor type II-like I (

Indexed as

anemiaepistaxisgastrointestinal hemorrhagehereditary hemorrhagictacrolimustelangiectasia

Identifiers

PMID36142926
PMCPMC9503120
OpenAlexW4295863855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.