Evidence map›Paper›PMID 36142843›Full record

ArticleInternational journal of molecular sciences2022

Pathogenesis of Tobacco-Associated Lung Adenocarcinoma Is Closely Coupled with Changes in the Gut and Lung Microbiomes.

Casey T Finnicum, Zahraa Rahal, Maya Hassane, Warapen Treekitkarnmongkol, Ansam Sinjab, Rhiannon Morris, Yuejiang Liu, Elizabeth L Tang, Sarah Viet, Jason L Petersen and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Casey T FinnicumAvera Institute for Human Genetics, Sioux Falls, SD 57108, USA.
Zahraa RahalDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-3595-7027
Maya HassaneFaculty of Medicine, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon.
Warapen TreekitkarnmongkolDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-7542-5201
Ansam SinjabDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0001-5777-227X
Rhiannon MorrisCollege of Natural Sciences, University of Texas at Austin, Austin, TX 78705, USA.
Yuejiang LiuDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Elizabeth L TangDepartment of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Sarah VietAvera Institute for Human Genetics, Sioux Falls, SD 57108, USA.
Jason L PetersenAvera Institute for Human Genetics, Sioux Falls, SD 57108, USA.
Philip L LorenziMetabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0003-0385-7774
Lin TanMetabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Joseph PetrosinoDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
Kristi L HoffmanDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
Junya FujimotoDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Seyed Javad MoghaddamUTHealth Houston Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-5350-307X
Humam KadaraDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
The University of Texas MD Anderson Cancer Center · USAvera Health · USBaylor College of Medicine · USAmerican University of Beirut · LBThe University of Texas at Austin · USUniversity of Illinois Urbana-Champaign · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Interplay between host microbiome and immunomodulatory responses in the pathogenesis of Kras mutant lung cancerR01CA248731 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KADARA, HUMAM, MOGHADDAM, SEYED JAVAD MIRHASSANI · 2021 to 2025
$2.5M
(PQ1) Progression of the airway field of injury to Kras mutant lung cancerR01CA205608 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KADARA, HUMAM, SCHEET, PAUL A · 2016 to 2019
$1.4M
Orbitrap Elite High-Resolution Mass Spectrometer for Proteomics and MetabolomicsS10OD012304 · OD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HAWKE, DAVID H · 2013 to 2013
$877k
NCI NIH HHS P30 CA016672NCI NIH HHS P30CA016672NCI NIH HHS R01 CA205608NCI NIH HHS R01CA205608NCI NIH HHS R01 CA248731NCI NIH HHS R01CA248731NCI NIH HHS S10OD012304-01NIH HHS S10 OD012304
6 · The paper itself

Abstract

Microbial dysbiosis has emerged as a modulator of oncogenesis and response to therapy, particularly in lung cancer. Here, we investigate the evolution of the gut and lung microbiomes following exposure to a tobacco carcinogen. We performed 16S rRNA-Seq of fecal and lung samples collected prior to and at several timepoints following (nicotine-specific nitrosamine ketone/NNK) exposure in

Indexed as

AdenocarcinomaAdenocarcinoma of LungLung NeoplasmsMicrobiotaNitrosaminesAnimalsButyratesCarcinogensDysbiosisGrowth InhibitorsHumansKetonesLungMiceNicotianaNicotineButyratesCarcinogensGPRC5A protein, humanGrowth InhibitorsKetonesNicotineNitrosaminesPropionatesReceptors, G-Protein-CoupledRNA, Ribosomal, 16S16S rRNA sequencinglung adenocarcinomamicrobiomesmoking

Identifiers

PMID36142843
PMCPMC9502774
OpenAlexW4296351477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.