Evidence map›Paper›PMID 36142814›Full record

ArticleInternational journal of molecular sciences2022

Identification of a Gene Panel Predictive of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy Employing Transcriptomic and Functional Validation.

Radhakrishnan Vishnubalaji, Hikmat Abdel-Razeq, Salahddin Gehani, Omar M E Albagha, Nehad M Alajez

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

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  10. Therapeutic targeting of the TPX2/TTK network in colorectal cancer.Cell communication and signaling : CCS · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Radhakrishnan VishnubalajiTranslational Cancer and Immunity Center (TCIC), Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha P.O. Box 34110, Qatar.
Hikmat Abdel-RazeqDepartment of Internal Medicine, King Hussein Cancer Center, Amman 11941, Jordan.ORCID 0000-0003-2833-6051
Salahddin GehaniHamad Medical Corporation, Doha P.O. Box 34110, Qatar.
Omar M E AlbaghaCollege of Health & Life Sciences, Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha P.O. Box 34110, Qatar.ORCID 0000-0001-5916-5983
Nehad M AlajezTranslational Cancer and Immunity Center (TCIC), Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha P.O. Box 34110, Qatar.ORCID 0000-0002-1546-1091
Hamad bin Khalifa University · QAEdinburgh Cancer Research · GBHamad Medical Corporation · QAUniversity of Jordan · JO

Funding

Qatar Biomedical Rsearch Institute QB13
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) patients exhibiting pathological complete response (pCR) have better clinical outcomes compared to those with residual disease (RD). Therefore, robust biomarkers that can predict pCR may help with triage and resource prioritization in patients with TNBC. Herein, we identified a gene panel predictive of RD and pCR in TNBC from the discovery (

Indexed as

Breast NeoplasmsCation Transport ProteinsTriple Negative Breast NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsDoxorubicinFemaleHumansNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm, ResidualTranscriptomeCation Transport ProteinsDoxorubicinSLC39A7 protein, humanneoadjuvant chemotherapypathological complete responsepredictive biomarkersresidual diseaseTNBC

Identifiers

PMID36142814
PMCPMC9506546
OpenAlexW4296352493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.