Evidence map›Paper›PMID 36142768›Full record

ArticleInternational journal of molecular sciences2022

Synthesis, Molecular Docking, In Vitro and In Vivo Studies of Novel Dimorpholinoquinazoline-Based Potential Inhibitors of PI3K/Akt/mTOR Pathway.

Maria V Zapevalova, Ekaterina S Shchegravina, Irina P Fonareva, Diana I Salnikova, Danila V Sorokin, Alexander M Scherbakov, Alexander A Maleev, Stanislav K Ignatov, Ivan D Grishin, Alexander N Kuimov and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Maria V ZapevalovaDepartment of Organic Chemistry, Nizhny Novgorod State University, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia.
Ekaterina S ShchegravinaDepartment of Organic Chemistry, Nizhny Novgorod State University, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia.ORCID 0000-0003-2194-1814
Irina P FonarevaDepartment of Organic Chemistry, Nizhny Novgorod State University, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia.
Diana I SalnikovaDepartment of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, Kashirskoye Sh. 24, 115522 Moscow, Russia.ORCID 0000-0002-0809-3710
Danila V SorokinDepartment of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, Kashirskoye Sh. 24, 115522 Moscow, Russia.
Alexander M ScherbakovDepartment of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, Kashirskoye Sh. 24, 115522 Moscow, Russia.ORCID 0000-0002-2974-9555
Alexander A MaleevDepartment of Organic Chemistry, Nizhny Novgorod State University, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia.
Stanislav K IgnatovDepartment of Organic Chemistry, Nizhny Novgorod State University, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia.
Ivan D GrishinDepartment of Organic Chemistry, Nizhny Novgorod State University, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia.
Alexander N KuimovA.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Leninskye Gory, House 1, Building 40, 119992 Moscow, Russia.
Maryia V KonovalovaDepartment of Immunology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.ORCID 0000-0003-3923-6304
Elena V SvirshchevskayaDepartment of Immunology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Alexey Yu FedorovDepartment of Organic Chemistry, Nizhny Novgorod State University, Gagarina Av. 23, 603950 Nizhny Novgorod, Russia.
Saratov State University · RUInstitute of Bioorganic Chemistry · RULomonosov Moscow State University · RU

Funding

Ministry of Science and Higher Education of the Russian Federation 13.1902.21.0004
6 · The paper itself

Abstract

A (series) range of potential dimorpholinoquinazoline-based inhibitors of the

Indexed as

Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktCell Line, TumorCell ProliferationMolecular Docking SimulationProtein Kinase InhibitorsQuinazolinesReactive Oxygen SpeciesTOR Serine-Threonine KinasesTriazinesUreaPhosphatidylinositol 3-KinasesProtein Kinase InhibitorsProto-Oncogene Proteins c-aktQuinazolinesReactive Oxygen SpeciesTOR Serine-Threonine KinasesTriazinesUreacancerdimorpholinoquinazolinekinase inhibition activityPI3K/Akt/mTOR inhibitorS6K

Identifiers

PMID36142768
PMCPMC9503112
OpenAlexW4296351515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.