Evidence map›Paper›PMID 36142730›Full record

ArticleInternational journal of molecular sciences2022

Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism.

Dimitrios Gazgalis, Lucas Cantwell, Yu Xu, Ganesh A Thakur, Meng Cui, Frank Guarnieri, Diomedes E Logothetis

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Mechanism of PKCε regulation of cardiac GIRK channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  5. PI(4,5)PAdvances in experimental medicine and biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dimitrios GazgalisDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Boston, MA 02115, USA.
Lucas CantwellDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Boston, MA 02115, USA.
Yu XuDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Boston, MA 02115, USA.
Ganesh A ThakurDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Boston, MA 02115, USA.
Meng CuiDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Boston, MA 02115, USA.
Frank GuarnieriCenter for Drug Discovery, Northeastern University, Boston, MA 02115, USA.
Diomedes E LogothetisDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Boston, MA 02115, USA.

Funding

Structural Determinants of PIP2 RegulationR01HL059949 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Leigh Daniel Plant · 1998 to 2026
$11.6M
NHLBI NIH HHS R01 HL059949NIH HHS R01 HL059949-24
6 · The paper itself

Abstract

G protein-gated inwardly rectifying K

Indexed as

G Protein-Coupled Inwardly-Rectifying Potassium ChannelsIon Channel GatingGTP-Binding ProteinsLipid BilayersPhosphatesPhosphatidylinositolsUreaG Protein-Coupled Inwardly-Rectifying Potassium ChannelsGTP-Binding ProteinsLipid BilayersPhosphatesPhosphatidylinositolsUreaGIRK1 heterotetramerMD simulationsML297PIP2TM1 hydrophobic wire

Identifiers

PMID36142730
PMCPMC9502415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.