ArticleInternational journal of molecular sciences2022
Functional Interactions of
Wasif Al-Shareef, Yogev Brown, Christopher Bryan, Elena Shuvaeva, Shhadeh Bsoul, Raanan Greenman, Majdi M Kabaha, Nikolai B Ulyanov, Emmanuel Skordalakes, Yehuda Tzfati
Open access · goldAbstract read
In one paragraphArticle in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors at 3 institutions in 2 countries.
Wasif Al-ShareefDepartment of Genetics, The Silberman Institute of Life Sciences, Edmond Safra Campus, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Yogev BrownDepartment of Genetics, The Silberman Institute of Life Sciences, Edmond Safra Campus, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Christopher BryanGene Expression and Regulation Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
Elena ShuvaevaGene Expression and Regulation Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.ORCID 0000-0001-5583-6639 Shhadeh BsoulDepartment of Genetics, The Silberman Institute of Life Sciences, Edmond Safra Campus, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Raanan GreenmanDepartment of Genetics, The Silberman Institute of Life Sciences, Edmond Safra Campus, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Majdi M KabahaDepartment of Genetics, The Silberman Institute of Life Sciences, Edmond Safra Campus, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Nikolai B UlyanovDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA.
Emmanuel SkordalakesGene Expression and Regulation Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.ORCID 0000-0002-7600-2833 Yehuda TzfatiDepartment of Genetics, The Silberman Institute of Life Sciences, Edmond Safra Campus, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.ORCID 0000-0001-7720-435X Hebrew University of Jerusalem · ILThe Wistar Institute · USUniversity of California, San Francisco · US
Funding
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9MTargeting telomerase for melanoma therapeuticsR01CA201312 · NCI · WISTAR INSTITUTE · PI SKORDALAKES, EMMANUEL · 2016 to 2020
$2.4MEuropean Molecular Biology Organization short-term fellowshipIsrael Science Foundation 2071/18NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA201312NCI NIH HHS RO1 CA201312-01The Wistar Institute P30 CA10815United States-Israel Binational Science Foundation 2009204United States-Israel Binational Science Foundation 2013344
6 · The paper itselfAbstract
The ribonucleoprotein telomerase contains two essential components: telomerase RNA (TER) and telomerase reverse transcriptase (TERT, Est2 in yeast). A small portion of TER, termed the template, is copied by TERT onto the chromosome ends, thus compensating for sequence loss due to incomplete DNA replication and nuclease action. Although telomerase RNA is highly divergent in sequence and length across fungi and mammals, structural motifs essential for telomerase function are conserved. Here, we show that Est2 from the budding yeast
Indexed as
KluyveromycesTelomeraseAnimalsBase SequenceMammalsNucleic Acid ConformationRNARNATelomerasetelomerase RNAcrystal structureEst2ribonucleoproteintelomerasetelomerase RNAthree-way junctionyeast
Identifiers
PMID36142669
PMCPMC9504884
OpenAlexW4296280801
What OpenQuestion holds
Textmetadata
LicenceCC BY
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