Evidence map›Paper›PMID 36142627›Full record

ArticleInternational journal of molecular sciences2022

Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone-Pyridylhydrazone Copper(II) Complex.

Xin Yi Choo, Lachlan E McInnes, Alexandra Grubman, Joanna M Wasielewska, Irina Belaya, Emma Burrows, Hazel Quek, Jorge Cañas Martín, Sanna Loppi, Annika Sorvari and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Mechanism of Metal Complexes in Alzheimer's Disease.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Xin Yi ChooDepartment of Pathology, The University of Melbourne, Parkville, VIC 3052, Australia.ORCID 0000-0002-1783-0102
Lachlan E McInnesSchool of Chemistry, Bio21 Institute for Molecular Science and Biotechnology, The University of Melbourne, Parkville, VIC 3052, Australia.
Alexandra GrubmanDepartment of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0003-4408-4499
Joanna M WasielewskaFaculty of Medicine, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0002-2423-7868
Irina BelayaA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.ORCID 0000-0001-7594-0679
Emma BurrowsFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3052, Australia.
Hazel QuekMental Health and Neuroscience, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.ORCID 0000-0001-5597-5372
Jorge Cañas MartínA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Sanna LoppiA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Annika SorvariA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.ORCID 0000-0001-9667-7654
Dzhessi RaitA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Andrew PowellCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Clare DuncanDepartment of Pathology, The University of Melbourne, Parkville, VIC 3052, Australia.
Jeffrey R LiddellDepartment of Pathology, The University of Melbourne, Parkville, VIC 3052, Australia.ORCID 0000-0002-0798-5338
Heikki TanilaA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Jose M PoloDepartment of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, Australia.
Tarja MalmA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Katja M KanninenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.ORCID 0000-0002-6717-8589
Paul S DonnellySchool of Chemistry, Bio21 Institute for Molecular Science and Biotechnology, The University of Melbourne, Parkville, VIC 3052, Australia.ORCID 0000-0001-5373-0080
Anthony R WhiteDepartment of Pathology, The University of Melbourne, Parkville, VIC 3052, Australia.ORCID 0000-0003-1802-9891
University of Eastern Finland · FIThe University of Melbourne · AUAustralian Regenerative Medicine Institute · AUThe University of Queensland · AUMonash University · AUQIMR Berghofer Medical Research Institute · AU

Funding

Australian Research Council (ARC) (ARC) DP150100649, DP160100288, DP200100178National Health and Medical Research Council of Australia (NHMRC) GNT0628946 and GNT1118452
6 · The paper itself

Abstract

Neuroinflammation has a major role in several brain disorders including Alzheimer's disease (AD), yet at present there are no effective anti-neuroinflammatory therapeutics available. Copper(II) complexes of bis(thiosemicarbazones) (Cu

Indexed as

Alzheimer DiseaseThiosemicarbazonesAnimalsChemotactic FactorsCoordination ComplexesCopperDisease Models, AnimalMembrane GlycoproteinsMetallothioneinMiceMicrogliaReceptors, ImmunologicTumor Necrosis Factor-alphaChemotactic FactorsCoordination ComplexesCoppercopper (II) diacetyl-di(N(4)-methylthiosemicarbazone)Membrane GlycoproteinsMetallothioneinReceptors, ImmunologicThiosemicarbazonesTrem2 protein, mouseTumor Necrosis Factor-alphaAlzheimer’s diseasecopperinflammationmicroglia

Identifiers

PMID36142627
PMCPMC9505367
OpenAlexW4295780103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.