Evidence map›Paper›PMID 36142624›Full record

ReviewInternational journal of molecular sciences2022

Modulation of Immune Cells as a Therapy for Cutaneous Lupus Erythematosus.

Jorge A Soto, Felipe Melo-González, Claudia A Riedel, Susan M Bueno, Alexis M Kalergis

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. What's New in Cutaneous Lupus Erythematosus: Guidelines, Biologics, and Beyond.The Journal of clinical and aesthetic dermatology · 2026
    Review
  3. Review
  4. Sex differences in mortality among patients with lupus nephritis.European journal of medical research · 2024
    Article
  5. Shedding Light on Skin Autoimmunity: More than Just Skin Deep.International journal of molecular sciences · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jorge A SotoMillennium Institute of Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.ORCID 0000-0003-0335-9759
Felipe Melo-GonzálezMillennium Institute of Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.ORCID 0000-0002-3711-2407
Claudia A RiedelMillennium Institute on Immunology and Immunotherapy, Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370146, Chile.
Susan M BuenoMillennium Institute of Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.ORCID 0000-0002-7551-8088
Alexis M KalergisMillennium Institute of Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.ORCID 0000-0001-7622-5263
Universidad Andrés Bello · CLPontificia Universidad Católica de Chile · CL

Funding

FONDEF D061008FONDEF D11I1080Fondo Nacional de Ciencia Tecnología e Innovación 1070352Fondo Nacional de Ciencia Tecnología e Innovación 11200764Fondo Nacional de Ciencia Tecnología e Innovación 1190830Millennium Institute on Immunology and Immunotherapy CN09_016 / ICN 2021_045; former P09/016-F.PAI ANID SA77210051
6 · The paper itself

Abstract

Cutaneous lupus erythematosus (CLE) is an autoimmune disorder like systemic lupus erythematosus (SLE). Both SLE and CLE characterize autoantibody secretion and immune cell recruitment. In particular, CLE can be divided into three more frequent types, varying in the severity of the skin lesions they present. The role of type I IFN was shown to be one of the leading causes of the development of this pathology in the skin. Different treatments have been developed and tested against these different variants of CLE to decrease the increasing levels of CLE in humans. In this article, a literature revision discussing the similarities between SLE and CLE is carried out. In addition, new advances in understanding the development of CLE and the leading treatments being evaluated in animal models and clinical trials are reviewed.

Indexed as

Lupus Erythematosus, CutaneousLupus Erythematosus, SystemicAnimalsHumansSkincutaneous lupus erythematosusimmune cellssystemic lupus erythematosustreatments

Identifiers

PMID36142624
PMCPMC9504747
OpenAlexW4295780182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.