Evidence map›Paper›PMID 36142605›Full record

ArticleInternational journal of molecular sciences2022

Identification of

Christian Faltus, Angelika Lahnsteiner, Myrto Barrdahl, Yassen Assenov, Anika Hüsing, Olga Bogatyrova, Marina Laplana, Theron Johnson, Thomas Muley, Michael Meister and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Christian FaltusDivision of Cancer Epigenomics, DKFZ-German Cancer Research Center, 69120 Heidelberg, Germany.
Angelika LahnsteinerDivision of Cancer (Epi-)Genetics, Department of Biosciences and Medical Biology, University of Salzburg, 5020 Salzburg, Austria.ORCID 0000-0001-7402-3369
Myrto BarrdahlDivision of Cancer Epidemiology, DKFZ-German Cancer Research Center, 69120 Heidelberg, Germany.
Yassen AssenovDivision of Cancer Epigenomics, DKFZ-German Cancer Research Center, 69120 Heidelberg, Germany.ORCID 0000-0002-6992-2092
Anika HüsingDivision of Cancer Epidemiology, DKFZ-German Cancer Research Center, 69120 Heidelberg, Germany.
Olga BogatyrovaDivision of Cancer Epigenomics, DKFZ-German Cancer Research Center, 69120 Heidelberg, Germany.
Marina LaplanaDivision of Cancer Epigenomics, DKFZ-German Cancer Research Center, 69120 Heidelberg, Germany.
Theron JohnsonDivision of Cancer Epidemiology, DKFZ-German Cancer Research Center, 69120 Heidelberg, Germany.
Thomas MuleyTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), 69120 Heidelberg, Germany.ORCID 0000-0002-8141-0604
Michael MeisterTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), 69120 Heidelberg, Germany.
Arne WarthTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), 69120 Heidelberg, Germany.
Michael ThomasTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), 69120 Heidelberg, Germany.ORCID 0000-0001-9511-055X
Christoph PlassDivision of Cancer Epigenomics, DKFZ-German Cancer Research Center, 69120 Heidelberg, Germany.
Rudolf KaaksDivision of Cancer Epidemiology, DKFZ-German Cancer Research Center, 69120 Heidelberg, Germany.
Angela RischDivision of Cancer Epigenomics, DKFZ-German Cancer Research Center, 69120 Heidelberg, Germany.ORCID 0000-0002-8026-5505
German Cancer Research Center · DEHeidelberg University · DEUniversitat de Lleida · ESUniversity of Salzburg · AT

Funding

German Cancer Research Center Helmholtz Graduate School (CF)German Center for Lung Research 82DZL00404
6 · The paper itself

Abstract

Changes in DNA methylation identified by epigenome-wide association studies (EWAS) have been recently linked to increased lung cancer risk. However, the cellular effects of these differentially methylated positions (DMPs) are often unclear. Therefore, we investigated top differentially methylated positions identified from an EWAS study. This included a putative regulatory region of

Indexed as

Epigenesis, GeneticLung NeoplasmsBiomarkersCpG IslandsDNA MethylationEpigenomeGenome-Wide Association StudyHumansProspective StudiesProto-Oncogene Proteins c-aktRNA, MessengerSerineUbiquitin-Protein LigasesAKT1 protein, humanBiomarkersNHLRC1 protein, humanProto-Oncogene Proteins c-aktRNA, MessengerSerineUbiquitin-Protein LigasesDNA methylationEWASlung cancerNHLRC1PI3K pathway activation

Identifiers

PMID36142605
PMCPMC9505874
OpenAlexW4295926279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.