Evidence map›Paper›PMID 36142531›Full record

ReviewInternational journal of molecular sciences2022

NLRP3 Inflammasome/Pyroptosis: A Key Driving Force in Diabetic Cardiomyopathy.

Lixia Zhang, Chenchen Ai, Ming Bai, Jinglei Niu, Zheng Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lixia ZhangThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China.
Chenchen AiCardiovascular Center, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730050, China.
Ming BaiThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China.
Jinglei NiuThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China.
Zheng ZhangThe First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China.

Funding

Natural science foundation of Gansu Province, China Grant NO. 21JR7RA364
6 · The paper itself

Abstract

Diabetic cardiomyopathy (DCM), a serious diabetic complication, is a kind of low-grade inflammatory cardiovascular disorder. Due to the high risk of morbidity and mortality, DCM has demanded the attention of medical researchers worldwide. The pathophysiological nature of DCM is intricate, and the genesis and development of which are a consequence of the coaction of many factors. However, the exact pathogenesis mechanism of DCM remains unclear. Pyroptosis is a newly identified programmed cell death (PCD) that is directly related to gasdermin D(GSDMD). It is characterized by pore formation on the cell plasma membrane, the release of inflammatory mediators, and cell lysis. The initiation of pyroptosis is closely correlated with NOD-like receptor 3 (NLRP3) activation, which activates caspase-1 and promotes the cleaving of GSDMD. In addition to adjusting the host's immune defense, NLRP3 inflammasome/pyroptosis plays a critical role in controlling the systemic inflammatory response. Recent evidence has indicated that NLRP3 inflammasome/pyroptosis has a strong link with DCM. Targeting the activation of NLRP3 inflammasome or pyroptosis may be a hopeful therapeutic strategy for DCM. The focus of this review is to summarize the relevant mechanisms of pyroptosis and the relative contributions in DCM, highlighting the potential therapeutic targets in this field.

Indexed as

Diabetes MellitusDiabetic CardiomyopathiesCaspase 1HumansInflammasomesInflammation MediatorsNLR Family, Pyrin Domain-Containing 3 ProteinNLR ProteinsPyroptosisCaspase 1InflammasomesInflammation MediatorsNLR Family, Pyrin Domain-Containing 3 ProteinNLR Proteinsdiabetic cardiomyopathyinhibitorNLRP3 inflammasomepyroptosis

Identifiers

PMID36142531
PMCPMC9501057

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.