Evidence map›Paper›PMID 36142498›Full record

ArticleInternational journal of molecular sciences2022

Association of Polymorphic Variants in Argonaute Genes with Depression Risk in a Polish Population.

Mateusz Kowalczyk, Edward Kowalczyk, Grzegorz Galita, Ireneusz Majsterek, Monika Talarowska, Tomasz Popławski, Paweł Kwiatkowski, Anna Lichota, Monika Sienkiewicz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Identification of a novelFrontiers in genetics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mateusz KowalczykBabinski Memorial Hospital, Aleksandrowska St. 159, 91-229 Lodz, Poland.
Edward KowalczykDepartment of Pharmacology and Toxicology, Medical University of Lodz, Zeligowskiego St. 7/9, 90-752 Lodz, Poland.
Grzegorz GalitaDepartment of Clinical Chemistry and Biochemistry, Medical University of Lodz, Mazowiecka 5, 92-215 Lodz, Poland.ORCID 0000-0002-1559-2796
Ireneusz MajsterekDepartment of Clinical Chemistry and Biochemistry, Medical University of Lodz, Mazowiecka 5, 92-215 Lodz, Poland.
Monika TalarowskaDepartment of Clinical Psychology and Psychopathology, Institute of Psychology, University of Lodz, Smugowa St. 10/12, 91-433 Lodz, Poland.ORCID 0000-0002-3451-1250
Tomasz PopławskiDepartment of Microbiology and Pharmaceutical Biochemistry, Medical University of Lodz, Mazowiecka 5, 92-215 Lodz, Poland.
Paweł KwiatkowskiDepartment of Diagnostic Immunology, Pomeranian Medical University in Szczecin, Powstancow Wielkopolskich Av. 72, 70-111 Szczecin, Poland.ORCID 0000-0003-0016-0541
Anna LichotaDepartment of Pharmaceutical Microbiology and Microbiological Diagnostic, Medical University of Lodz, Muszynskiego St. 1, 90-151 Lodz, Poland.ORCID 0000-0002-5399-3144
Monika SienkiewiczDepartment of Pharmaceutical Microbiology and Microbiological Diagnostic, Medical University of Lodz, Muszynskiego St. 1, 90-151 Lodz, Poland.ORCID 0000-0002-9823-4176
Medical University of Lodz · PLPomeranian Medical University · PLUniversity of Łódź · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Argonaute (AGO) proteins, through their key role in the regulation of gene expression, participate in many biological processes, including cell differentiation, proliferation, death and DNA repair. Accurate regulation of gene expression appears to be important for the proper development of complex neural circuits. Loss of AGO proteins is known to lead to early embryonic mortality in mice with various malformations, including anomalies of the central nervous system. Single-nucleotide polymorphisms (SNPs) of AGO genes can lead to deregulation of the processes in which AGO proteins are involved. The contribution of different SNPs in depression has been extensively studied. However, there are hardly any studies on the contribution of AGO genes. The aim of our research was to assess the relationship between the occurrence of depression and the presence of SNPs in genes AGO1 (rs636882) and AGO2 (rs4961280; rs2292779; rs2977490) in a Polish population. One hundred and one subjects in the study group were diagnosed with recurrent depressive disorder by a psychiatrist. The control group comprised 117 healthy subjects. Study participants performed the HDRS (Hamilton Depression Scale) test to confirm or exclude depression and assess severity. The frequency of polymorphic variants of genes AGO1 (rs636882) and AGO2 (rs4961280; rs2292779; rs2977490) was determined using TaqMan SNP genotyping assays and the TaqMan universal PCR master mix, no AmpErase UNG. The rs4961280/AGO2 polymorphism was associated with a decrease in depression occurrence in the codominant (OR = 0.51,

Indexed as

DepressionAllelesAnimalsArgonaute ProteinsCase-Control StudiesEukaryotic Initiation FactorsHumansMicePolandPolymorphism, Single NucleotideAGO1 protein, humanAGO2 protein, humanArgonaute ProteinsEukaryotic Initiation FactorsAGOargonautedepressionpolymorphism

Identifiers

PMID36142498
PMCPMC9500920
OpenAlexW4296002935

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.