Evidence map›Paper›PMID 36142484›Full record

ArticleInternational journal of molecular sciences2022

SPIN90 Deficiency Ameliorates Amyloid β Accumulation by Regulating APP Trafficking in AD Model Mice.

Youngsoo Oh, Wongyoung Lee, So Hee Kim, Sooji Lee, Byeong C Kim, Kun Ho Lee, Sung Hyun Kim, Woo Keun Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Youngsoo OhCell Logistics Research Center, School of Life Science, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Wongyoung LeeDepartment of Neuroscience, Graduate School, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0003-2731-3245
So Hee KimCell Logistics Research Center, School of Life Science, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Sooji LeeDepartment of Medicine, School of Medicine, Kyung Hee University, Seoul 02447, Korea.
Byeong C KimDepartment of Neurology, Chonnam National University Medical School, Gwangju 61469, Korea.ORCID 0000-0001-6827-6730
Kun Ho LeeGwangju Alzheimer's Disease and Related Dementia Cohort Research Center, Chosun University, Gwangju 61452, Korea.ORCID 0000-0003-4144-8162
Sung Hyun KimDepartment of Neuroscience, Graduate School, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0002-3166-9941
Woo Keun SongCell Logistics Research Center, School of Life Science, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Kyung Hee University · KRChosun University · KRGwangju Institute of Science and Technology · KR

Funding

Ministry of Oceans and Fisheries 20210633National Research Foundation of Korea 2016R1A5A1007318, 2020R1A2C2010791, 2018R1A6A03025124,2021R1A6A3A13044869
6 · The paper itself

Abstract

Alzheimer's disease (AD), a common form of dementia, is caused in part by the aggregation and accumulation in the brain of amyloid β (Aβ), a product of the proteolytic cleavage of amyloid precursor protein (APP) in endosomes. Trafficking of APP, such as surface-intracellular recycling, is an early critical step required for Aβ generation. Less is known, however, about the molecular mechanism regulating APP trafficking. This study investigated the mechanism by which SPIN90, along with Rab11, modulates APP trafficking, Aβ motility and accumulation, and synaptic functionality. Brain Aβ deposition was lower in the progeny of 5xFAD-SPIN90KO mice than in 5xFAD-SPIN90WT mice. Analysis of APP distribution and trafficking showed that the surface fraction of APP was locally distinct in axons and dendrites, with these distributions differing significantly in 5xFAD-SPIN90WT and 5xFAD-SPIN90KO mice, and that neural activity-driven APP trafficking to the surface and intracellular recycling were more actively mobilized in 5xFAD-SPIN90KO neurons. In addition, SPIN90 was found to be cotrafficked with APP via axons, with ablation of SPIN90 reducing the intracellular accumulation of APP in axons. Finally, synaptic transmission was restored over time in 5xFAD-SPIN90KO but not in 5xFAD-SPIN90WT neurons, suggesting SPIN90 is implicated in Aβ production through the regulation of APP trafficking.

Indexed as

Adaptor Proteins, Signal TransducingAlzheimer DiseaseAmyloid beta-Protein PrecursorNerve Tissue ProteinsAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAnimalsAxonsDisease Models, AnimalMiceMice, TransgenicNeuronsAdaptor Proteins, Signal TransducingAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesNerve Tissue ProteinsSPIN90 protein, mouseAlzheimer’s diseaseAmyloid β accumulationAPP recyclingAPP traffickingRab11SPIN90synaptic transmission

Identifiers

PMID36142484
PMCPMC9504172
OpenAlexW4295846907

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.