Evidence map›Paper›PMID 36142474›Full record

ArticleInternational journal of molecular sciences2022

Precision Killing of Sinoporphyrin Sodium-Mediated Photodynamic Therapy against Malignant Tumor Cells.

Guixiang Lv, Zhihui Dong, Yunhan Zhao, Ning Ma, Xiaochen Jiang, Jia Li, Jinyue Wang, Jiaxin Wang, Wenxiu Zhang, Xin Lin and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Guixiang LvDepartment of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China.ORCID 0000-0001-5547-5255
Zhihui DongDepartment of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China.
Yunhan ZhaoDepartment of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China.
Ning MaDepartment of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China.
Xiaochen JiangDepartment of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China.
Jia LiDepartment of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China.
Jinyue WangDepartment of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China.
Jiaxin WangDepartment of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China.
Wenxiu ZhangDepartment of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China.
Xin LinDepartment of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China.
Zheng HuDepartment of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China.ORCID 0000-0002-3323-0369
Harbin Medical University · CN

Funding

HMU Marshal Initiative Funding HMUMIF-21025National Natural Science Foundation of China 81702925National Natural Science Foundation of China 81727809
6 · The paper itself

Abstract

Photodynamic therapy (PDT) has significant advantages in the treatment of malignant tumors, such as high efficiency, minimal invasion and less side effects, and it can preserve the integrity and quality of the organs. The power density, irradiation time and photosensitizer (PS) concentration are three main parameters that play important roles in killing tumor cells. However, until now, the underlying relationships among them for PDT outcomes have been unclear. In this study, human malignant glioblastoma U-118MG and melanoma A375 cells were selected, and the product of the power density, irradiation time and PS concentration was defined as the total photodynamic parameter (TPP), in order to investigate the mechanisms of PS sinoporphyrin sodium (DVDMS)-mediated PDT (DVDMS-PDT). The results showed that the survival rates of the U-118MG and A375 cells were negatively correlated with the TPP value in the curve, and the correlation exactly filed an

Indexed as

PhotochemotherapyPorphyrinsCell Line, TumorHumansPhotosensitizing AgentsPhotosensitizing AgentsPorphyrinssinoporphyrin sodiumdosimetrye-exponential functionoutcomesparametersphotodynamic therapy

Identifiers

PMID36142474
PMCPMC9503352
OpenAlexW4295846854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.