Evidence map›Paper›PMID 36142472›Full record

ReviewInternational journal of molecular sciences2022

Albumin as a Biomaterial and Therapeutic Agent in Regenerative Medicine.

Olga Kuten Pella, István Hornyák, Dénes Horváthy, Eszter Fodor, Stefan Nehrer, Zsombor Lacza

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Olga Kuten PellaOrthosera GmbH, 3500 Krems an der Donau, Austria.ORCID 0000-0002-1827-1314
István HornyákInstitute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary.ORCID 0000-0002-7183-8973
Dénes HorváthyDepartment of Interventional Radiology, Semmelweis University, 1122 Budapest, Hungary.ORCID 0000-0001-8136-7100
Eszter FodorInstitute for Sports and Health Sciences, Hungarian University of Sports Science, 1123 Budapest, Hungary.ORCID 0000-0002-9487-2824
Stefan NehrerCenter for Regenerative Medicine, Danube University Krems, 3500 Krems an der Donau, Austria.ORCID 0000-0001-8008-2226
Zsombor LaczaOrthosera GmbH, 3500 Krems an der Donau, Austria.
Semmelweis University · HUHungarian School Sport Federation · HUUniversität für Weiterbildung Krems · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Albumin is a constitutional plasma protein, with well-known biological functions, e.g., a nutrient for stem cells in culture. However, albumin is underutilized as a biomaterial in regenerative medicine. This review summarizes the advanced therapeutic uses of albumin, focusing on novel compositions that take advantage of the excellent regenerative potential of this protein. Albumin coating can be used for enhancing the biocompatibility of various types of implants, such as bone grafts or sutures. Albumin is mainly known as an anti-attachment protein; however, using it on implantable surfaces is just the opposite: it enhances stem cell adhesion and proliferation. The anticoagulant, antimicrobial and anti-inflammatory properties of albumin allow fine-tuning of the biological reaction to implantable tissue-engineering constructs. Another potential use is combining albumin with natural or synthetic materials that results in novel composites suitable for cardiac, neural, hard and soft tissue engineering. Recent advances in materials have made it possible to electrospin the globular albumin protein, opening up new possibilities for albumin-based scaffolds for cell therapy. Several described technologies have already entered the clinical phase, making good use of the excellent biological, but also regulatory, manufacturing and clinical features of serum albumin.

Indexed as

Biocompatible MaterialsRegenerative MedicineAnticoagulantsSerum AlbuminTissue EngineeringTissue ScaffoldsAnticoagulantsBiocompatible MaterialsSerum Albuminalbuminbone allograftregenerative medicinescaffoldsserum albumin

Identifiers

PMID36142472
PMCPMC9502107
OpenAlexW4295846941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.