SynthesisInternational journal of molecular sciences2022
Tissue Characteristics in Endodontic Regeneration: A Systematic Review.
Synthesis in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Review
- Tissue characteristics in a traumatised immature necrotic incisor after unsuccessful regenerative endodontic treatment: an immunohistological case report.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Establishment of a regenerative endodontic procedures model of mature mouse teeth and evaluation of the wound healing process.Odontology · 2026Article
- Effect of Chitosan Nanoparticles as an Irrigant in Regenerative Endodontic Therapy of Necrotic Immature Permanent Teeth: An In Vivo Dog Model Study.Biomedicines · 2026Article
- Regeneration Versus Granulation Tissue Healing in a Hopeless Mature Mandibular Molar Post-Endodontic Management: A 40-Month Follow-Up Case Report.Dentistry journal · 2026Article
- Regenerative Endodontic Treatment in Permanent Incisors: Two Case Reports with 6 Years of Follow-Up.Children (Basel, Switzerland) · 2026Article
- Regenerative endodontics: current concepts, clinical challenges, and emerging therapies.Brazilian oral research · 2026Review
- Enamel Matrix Derivative in Dental Pulp Regeneration: Biological Basis, Mechanistic Insights, and Translational Considerations.Stem cells international · 2026Review
- Regenerative Endodontic Procedure (REP) of a Previously Treated, Infected, Immature Permanent Incisor.Case reports in dentistry · 2026Article
- Concentration-dependent effects of modified triple antibiotic paste on human periodontal ligament stem cells and antibacterial efficacy: an in vitro study.The Saudi dental journal · 2025Article
- A clinical study on the preservation of pulp sensitivity in affected teeth with jaw cysts using concentrated growth factor: a retrospective Cross-sectional study.Scientific reports · 2025Article
- Influence of photobiomodulation therapy on regenerative potential of non-vital mature permanent teeth in healthy canine dogs.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Article
- Biological and mechanical challenges in the endodontic treatment of immature teeth with pulp necrosis: insights based on a Series of Atypical Clinical Cases.Biomaterial investigations in dentistry · 2025Article
- Dental pulp mesenchymal stem cells-response to fibrin hydrogel reveals ITGA2 and MMPs expression.Heliyon · 2024Article
- Revascularization of a Permanent Tooth with Necrotic Pulp and Apical Periodontitis.Clinical, cosmetic and investigational dentistry · 2024Article
- Engineering the Future of Dental Health: Exploring Molecular Advancements in Dental Pulp Regeneration.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regenerative endodontic procedure (REP) represents a treatment option for immature necrotic teeth with a periapical lesion. Currently, this therapy has a wide field of pre-clinical and clinical applications, but no standardization exists regarding successful criteria. Thus, by analysis of animal and human studies, the aim of this systematic review was to highlight the main characteristics of the tissue generated by REP. A customized search of PubMed, EMBASE, Scopus, and Web of Science databases from January 2000 to January 2022 was conducted. Seventy-five human and forty-nine animal studies were selected. In humans, the evaluation criteria were clinical 2D and 3D radiographic examinations. Most of the studies identified a successful REP with an asymptomatic tooth, apical lesion healing, and increased root thickness and length. In animals, histological and radiological criteria were considered. Newly formed tissues in the canals were fibrous, cementum, or bone-like tissues along the dentine walls depending on the area of the root. REP assured tooth development and viability. However, further studies are needed to identify procedures to successfully reproduce the physiological structure and function of the dentin-pulp complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.