Evidence map›Paper›PMID 36142409›Full record

ArticleInternational journal of molecular sciences2022

TTYH3 Modulates Bladder Cancer Proliferation and Metastasis via FGFR1/H-Ras/A-Raf/MEK/ERK Pathway.

Polash Kumar Biswas, Yeonjoo Kwak, Aram Kim, Jaekwon Seok, Hee Jeong Kwak, Moonjung Lee, Ahmed Abdal Dayem, Kwonwoo Song, Jae-Yong Park, Kyoung Sik Park and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
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  4. [Apelin promotes proliferation, migration, and angiogenesis in bladder cancer by activating the FGF2/FGFR1 pathway].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  5. Article
  6. Calcium channels as pharmacological targets for cancer therapy.Clinical and experimental medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Polash Kumar BiswasDepartment of Stem Cell & Regenerative Biotechnology, Institute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
Yeonjoo KwakDepartment of Stem Cell & Regenerative Biotechnology, Institute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
Aram KimDepartment of Urology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 05029, Korea.
Jaekwon SeokDepartment of Stem Cell & Regenerative Biotechnology, Institute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
Hee Jeong KwakDepartment of Stem Cell & Regenerative Biotechnology, Institute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
Moonjung LeeDepartment of Advanced Translational Medicine, Konkuk University, Seoul 05029, Korea.
Ahmed Abdal DayemDepartment of Stem Cell & Regenerative Biotechnology, Institute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
Kwonwoo SongDepartment of Stem Cell & Regenerative Biotechnology, Institute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
Jae-Yong ParkSchool of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 05029, Korea.ORCID 0000-0001-7698-7890
Kyoung Sik ParkDepartment of Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 05029, Korea.
Hyun Jin ShinDepartment of Ophthalmology, Research Institute of Medical Science, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 05029, Korea.ORCID 0000-0002-3563-8042
Ssang-Goo ChoDepartment of Stem Cell & Regenerative Biotechnology, Institute of Advanced Regenerative Science, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.ORCID 0000-0002-0968-7932
Konkuk University · KRKonkuk University Medical Center · KRKorea University · KR

Funding

Konkuk University 2019
6 · The paper itself

Abstract

Tweety family member 3 (TTYH3) is a calcium-activated chloride channel with a non-pore-forming structure that controls cell volume and signal transduction. We investigated the role of TTYH3 as a cancer-promoting factor in bladder cancer. The mRNA expression of

Indexed as

MAP Kinase Signaling SystemUrinary Bladder NeoplasmsCell Line, TumorCell ProliferationChloride ChannelsHumansMitogen-Activated Protein Kinase KinasesReceptor, Fibroblast Growth Factor, Type 1RNA, MessengerChloride ChannelsFGFR1 protein, humanMitogen-Activated Protein Kinase KinasesReceptor, Fibroblast Growth Factor, Type 1RNA, MessengerTTYH3 protein, humanbladder cancerFGFR1gene expressionMAPKpatient survivalTTYH3

Identifiers

PMID36142409
PMCPMC9501546
OpenAlexW4296793858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.