Evidence map›Paper›PMID 36142381›Full record

ArticleInternational journal of molecular sciences2022

Peripheral Blood DNA Methylation Profiles Do Not Predict Endoscopic Post-Operative Recurrence in Crohn's Disease Patients.

Vincent W Joustra, Andrew Y F Li Yim, Jessica R de Bruyn, Marjolijn Duijvestein, Ishtu L Hageman, Wouter J de Jonge, Peter Henneman, Manon Wildenberg, Geert D'Haens

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Vincent W JoustraDepartment of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0003-4157-7220
Andrew Y F Li YimGenome Diagnostics Laboratory, Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0002-0754-0953
Jessica R de BruynTytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, 1105 BK Amsterdam, The Netherlands.
Marjolijn DuijvesteinDepartment of Gastroenterology and Hepatology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-4814-9376
Ishtu L HagemanTytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, 1105 BK Amsterdam, The Netherlands.ORCID 0000-0002-3180-156X
Wouter J de JongeTytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, 1105 BK Amsterdam, The Netherlands.ORCID 0000-0002-3241-1547
Peter HennemanGenome Diagnostics Laboratory, Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Manon WildenbergTytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, 1105 BK Amsterdam, The Netherlands.
Geert D'HaensDepartment of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Amsterdam University Medical Centers · NLRadboud University Nijmegen · NL

Funding

Leona M. and Harry B. Helmsley Charitable Trust 2019PG-CD027
6 · The paper itself

Abstract

Prediction of endoscopic post-operative recurrence (POR) in Crohn's disease (CD) patients following ileocolonic resection (ICR) using clinical risk factors alone has thus far been inadequate. While peripheral blood leukocyte (PBL) DNA methylation has shown promise as a tool for predicting recurrence in cancer, no data in CD patients exists. Therefore, this study explored the association and predictive value of PBL DNA methylation in CD patients following ICR. From a cohort of 117 CD patients undergoing ICR, epigenome-wide PBL methylation profiles from 25 carefully selected patients presenting either clear endoscopic remission (

Indexed as

Crohn DiseaseDNA MethylationEndoscopyEpigenomeHumansPostoperative PeriodRecurrenceDNA methylationendoscopic recurrenceepigeneticspersonalized medicinepredictive biomarker

Identifiers

PMID36142381
PMCPMC9503775
OpenAlexW4296807034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.