Evidence map›Paper›PMID 36142379›Full record

ArticleInternational journal of molecular sciences2022

Novel Planar Pt(II) Cyclometallated Cytotoxic Complexes with G-Quadruplex Stabilisation and Luminescent Properties.

Brondwyn S McGhie, Jennette Sakoff, Jayne Gilbert, Christopher P Gordon, Janice R Aldrich-Wright

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Brondwyn S McGhieSchool of Science, Western Sydney University, Locked Bag 1797 Penrith South DC, Penrith, NSW 2751, Australia.ORCID 0000-0003-2442-7570
Jennette SakoffCalvary Mater Newcastle, Waratah, Newcastle, NSW 2298, Australia.
Jayne GilbertCalvary Mater Newcastle, Waratah, Newcastle, NSW 2298, Australia.
Christopher P GordonSchool of Science, Western Sydney University, Locked Bag 1797 Penrith South DC, Penrith, NSW 2751, Australia.
Janice R Aldrich-WrightSchool of Science, Western Sydney University, Locked Bag 1797 Penrith South DC, Penrith, NSW 2751, Australia.ORCID 0000-0002-6943-6908
Western Sydney University · AUCalvary Mater Newcastle Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein is described the development of a series of novel quadruplex DNA (QDNA)-stabilising cyclometallated square-planar metal complexes (CMCs). Melting experiments using quadruplex DNA (QDNA) demonstrated that interactions with the complexes increased the melting temperature by up to 19 °C. This QDNA stabilisation was determined in two of the major G-quadruplex structures formed in the human c-MYC promoter gene (c-MYC) and a human telomeric repeat sequence (H-Telo). The CMCs were found to stabilise H-telo more strongly than c-MYC, and the CMCs with the highest cytotoxic effect had a low-moderate correlation between H-telo binding capacity and cytotoxicity (R

Indexed as

Antineoplastic AgentsCoordination ComplexesG-QuadruplexesCisplatinGenes, mycHumansTelomereAntineoplastic AgentsCisplatinCoordination ComplexesanticancercyclometallatedG-quadruplexPt(II)

Identifiers

PMID36142379
PMCPMC9499473
OpenAlexW4296806894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.