Evidence map›Paper›PMID 36142376›Full record

ArticleInternational journal of molecular sciences2022

The Effects of Intravitreal Administration of Antifungal Drugs on the Structure and Mechanical Properties Peripheral Blood Erythrocyte Surface in Rabbits.

Maria N Starodubtseva, Sofia Karachrysafi, Nastassia M Shkliarava, Irina A Chelnokova, Dimitrios Kavvadas, Kyriaki Papadopoulou, Paraskevi Samara, Vasileios Papaliagkas, Antonia Sioga, Anastasia Komnenou and 2 more

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In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria N StarodubtsevaInstitute of Radiobiology of the NAS of Belarus, 4, Fedyuninskogo St., 246007 Gomel, Belarus.ORCID 0000-0002-8516-0884
Sofia KarachrysafiLaboratory of Histology, Embryology, Medical Department, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-6309-8410
Nastassia M ShkliaravaInstitute of Radiobiology of the NAS of Belarus, 4, Fedyuninskogo St., 246007 Gomel, Belarus.ORCID 0000-0002-6365-3856
Irina A ChelnokovaInstitute of Radiobiology of the NAS of Belarus, 4, Fedyuninskogo St., 246007 Gomel, Belarus.
Dimitrios KavvadasLaboratory of Histology, Embryology, Medical Department, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-3325-2752
Kyriaki PapadopoulouLaboratory of Histology, Embryology, Medical Department, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Paraskevi SamaraMRes Applied Health Research, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.
Vasileios PapaliagkasDepartment of Biomedical Sciences, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece.ORCID 0000-0003-1064-0290
Antonia SiogaLaboratory of Histology, Embryology, Medical Department, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Anastasia KomnenouSchool of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 57400 Thessaloniki, Greece.
Vasileios KarampatakisLaboratory of Experimental Ophthalmology, Medical Department, Faculty of Health Sciences, Aristotle University of Thessaloniki, 57400 Thessaloniki, Greece.
Theodora PapamitsouLaboratory of Histology, Embryology, Medical Department, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-0709-5407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFungal infections can pose great threat to sight. Immediate treatment is usually required; antifungal agents are widely accepted and are effective in most cases. The present experimental study aims to investigate the probable effects of intravitreal injection of antifungal agents on the structure and mechanical properties of the surface of peripheral blood erythrocytes.

methodsNine albino New Zealand white rabbits, aged five months old, were chosen for the experiment. Solutions of micafungin, voriconazole, or balanced salt solution (BSS) were injected into the midvitreous. Animals were divided into two experimental groups and one control group. Blood sampling from an intravenous (IV) line was performed after 10 days from the last IV injection. An atomic force microscope (AFM) was used to study the structural and mechanical properties of cell surfaces.

resultsThe analysis results showed that the parameters of the cytoskeleton's spatial organization changed insignificantly with the antifungal drug treatment.

conclusionsOur findings suggest that locally administered antifungal drugs can cause significant changes to the structure and frictional properties of the erythrocyte surface. These effects occur in the long-term period after administration of the drugs and represent a potential possibility for violation of blood supply to tissues, and the further development of negative side effects.

Indexed as

Antifungal AgentsMycosesAnimalsErythrocytesMicafunginRabbitsVoriconazoleAntifungal AgentsMicafunginVoriconazoleantifungal agentsatomic force microscopyerythrocytesmicafunginvoriconazole

Identifiers

PMID36142376
PMCPMC9499686

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.