Evidence map›Paper›PMID 36142368›Full record

ArticleInternational journal of molecular sciences2022

The Comparative Experimental Study of Sodium and Magnesium Dichloroacetate Effects on Pediatric PBT24 and SF8628 Cell Glioblastoma Tumors Using a Chicken Embryo Chorioallantoic Membrane Model and on Cells In Vitro.

Eligija Damanskienė, Ingrida Balnytė, Angelija Valančiūtė, Vaiva Lesauskaitė, Marta Marija Alonso, Donatas Stakišaitis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Eligija DamanskienėDepartment of Histology and Embryology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Ingrida BalnytėDepartment of Histology and Embryology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Angelija ValančiūtėDepartment of Histology and Embryology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.ORCID 0000-0003-3611-2509
Vaiva LesauskaitėLaboratory of Molecular Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, Sukileliu Ave., 50161 Kaunas, Lithuania.ORCID 0000-0003-2736-3111
Marta Marija AlonsoClínica Universidad de Navarra, Department of Pediatrics, University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-7520-7351
Donatas StakišaitisDepartment of Histology and Embryology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.ORCID 0000-0002-1547-7050
Lithuanian University of Health Sciences · LTClinica Universidad de Navarra · ES

Funding

Lietuvos Mokslo Taryba P-MIP-20-36.
6 · The paper itself

Abstract

In this study, pyruvate dehydrogenase kinase-1 inhibition with dichloroacetate (DCA) was explored as an alternative cancer therapy. The study's aim was to compare the effectiveness of NaDCA and MgDCA on pediatric glioblastoma PBT24 and SF8628 tumors and cells. The treatment effects were evaluated on xenografts growth on a chicken embryo chorioallantoic membrane. The PCNA, EZH2, p53, survivin expression in tumor, and the

Indexed as

GlioblastomaAcetatesAnimalsChick EmbryoChickensChorioallantoic MembraneDichloroacetic AcidHumansMagnesiumMonocarboxylic Acid TransportersProliferating Cell Nuclear AntigenPyruvate Dehydrogenase Acetyl-Transferring KinaseSodiumSolute Carrier Family 12, Member 2SurvivinTumor Suppressor Protein p53AcetatesDichloroacetic AcidMagnesiumMonocarboxylic Acid TransportersProliferating Cell Nuclear AntigenPyruvate Dehydrogenase Acetyl-Transferring KinaseSLC12A2 protein, humanSLC5A8 protein, humanSodiumSolute Carrier Family 12, Member 2SurvivinTumor Suppressor Protein p53CAM modeldichloroacetategene expressionPBT24pediatric glioblastomasexSF8628

Identifiers

PMID36142368
PMCPMC9499689
OpenAlexW4295537361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.