Evidence map›Paper›PMID 36142363›Full record

ArticleInternational journal of molecular sciences2022

Clomifene and Assisted Reproductive Technology in Humans Are Associated with Sex-Specific Offspring Epigenetic Alterations in Imprinted Control Regions.

Dillon T Lloyd, Harlyn G Skinner, Rachel Maguire, Susan K Murphy, Alison A Motsinger-Reif, Cathrine Hoyo, John S House

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Dillon T LloydCenter for Human Health and the Environment, North Carolina State University, Raleigh, NC 27606, USA.
Harlyn G SkinnerCenter for Human Health and the Environment, North Carolina State University, Raleigh, NC 27606, USA.
Rachel MaguireCenter for Human Health and the Environment, North Carolina State University, Raleigh, NC 27606, USA.
Susan K MurphyDepartment of Obstetrics and Gynecology, Duke University Medical Center, Duke University, Durham, NC 27701, USA.ORCID 0000-0001-8298-7272
Alison A Motsinger-ReifDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Cathrine HoyoCenter for Human Health and the Environment, North Carolina State University, Raleigh, NC 27606, USA.
John S HouseCenter for Human Health and the Environment, North Carolina State University, Raleigh, NC 27606, USA.ORCID 0000-0002-8447-7871
National Institutes of Health · USNorth Carolina State University · USDuke Medical Center · US

Funding

Translational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Andrew R. Binder · 2015 to 2026
$18.3M
Nutrition, Deregulation of Imprinted GenesR01ES016772 · NIEHS · DUKE UNIVERSITY · PI HOYO, CATHRINE · 2009 to 2013
$3.1M
Maternal obesity, child executive functions and child weight gainR01HD084487 · NICHD · DUKE UNIVERSITY · PI FUEMMELER, BERNARD F, SCHECHTER, JULIA CORWIN · 2015 to 2019
$3.0M
Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) CohortR24ES028531 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HOYO, CATHRINE, MURPHY, SUSAN KAY · 2018 to 2022
$1.9M
In-utero Exposure and Infant Loss of IGF2 ImprintingR21ES014947 · NIEHS · DUKE UNIVERSITY · PI HOYO, CATHRINE · 2006 to 2007
$384k
NICHD NIH HHS R01 HD084487NIEHS NIH HHS Intramural Research ProgramNIEHS NIH HHS P30 ES025128NIEHS NIH HHS R01 ES016772NIEHS NIH HHS R21 ES014947NIEHS NIH HHS R24 ES028531NIH HHS P30ES025128NIH HHS R01ES016772NIH HHS R01HD084487NIH HHS R21ES014947NIH HHS R24ES028531
6 · The paper itself

Abstract

Children conceived with assisted reproductive technology (ART) have an increased risk of adverse outcomes, including congenital malformations and imprinted gene disorders. In a retrospective North Carolina-based-birth-cohort, we examined the effect of ovulation drugs and ART on CpG methylation in differentially methylated CpGs in known imprint control regions (ICRs). Nine ICRs containing 48 CpGs were assessed for methylation status by pyrosequencing in mixed leukocytes from cord blood. After restricting to non-smoking, college-educated participants who agreed to follow-up, ART-exposed (

Indexed as

ClomipheneGenomic ImprintingChildDNA MethylationFemaleHumansMaleReproductive Techniques, AssistedRetrospective StudiesClomipheneadverse offspring outcomesdifferentially methylated regionsinfertility

Identifiers

PMID36142363
PMCPMC9499479
OpenAlexW4296799595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.