Evidence map›Paper›PMID 36142359›Full record

ArticleInternational journal of molecular sciences2022

New Inhibitors of the Human p300/CBP Acetyltransferase Are Selectively Active against the Arabidopsis HAC Proteins.

Chiara Longo, Andrea Lepri, Andrea Paciolla, Antonella Messore, Daniela De Vita, Maria Carmela Bonaccorsi di Patti, Matteo Amadei, Valentina Noemi Madia, Davide Ialongo, Roberto Di Santo and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Chiara LongoDepartment of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, 00185 Rome, Italy.
Andrea LepriDepartment of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-0742-6157
Andrea PaciollaDepartment of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-0997-4744
Antonella MessoreDepartment of Chemistry and Technology of Drug, Sapienza University of Rome, Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 00185 Rome, Italy.
Daniela De VitaDepartment of Environmental Biology, Sapienza University of Rome, 00185 Rome, Italy.
Maria Carmela Bonaccorsi di PattiDepartment of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-4794-7037
Matteo AmadeiDepartment of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Valentina Noemi MadiaDepartment of Chemistry and Technology of Drug, Sapienza University of Rome, Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 00185 Rome, Italy.ORCID 0000-0002-5724-612X
Davide IalongoDepartment of Chemistry and Technology of Drug, Sapienza University of Rome, Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 00185 Rome, Italy.ORCID 0000-0002-4672-2936
Roberto Di SantoDepartment of Chemistry and Technology of Drug, Sapienza University of Rome, Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 00185 Rome, Italy.ORCID 0000-0002-4279-7666
Roberta CostiDepartment of Chemistry and Technology of Drug, Sapienza University of Rome, Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 00185 Rome, Italy.
Paola VittoriosoDepartment of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-4189-5168
Sapienza University of Rome · ITIstituto Pasteur · IT

Funding

Sapienza University of Rome RM11916B7AB04C71
6 · The paper itself

Abstract

Histone acetyltransferases (HATs) are involved in the epigenetic positive control of gene expression in eukaryotes. CREB-binding proteins (CBP)/p300, a subfamily of highly conserved HATs, have been shown to function as acetylases on both histones and non-histone proteins. In the model plant

Indexed as

ArabidopsisArabidopsis ProteinsAcetylationArsenate ReductasesCREB-Binding ProteinEthylenesHistone AcetyltransferasesHistonesHumansMediator Complexp300-CBP Transcription FactorsArabidopsis ProteinsArsenate ReductasesCREB-Binding ProteinEthylenesHAC1 (HIGH ARSENIC CONTENT 1) protein, ArabidopsisHistone AcetyltransferasesHistonesMediator Complexp300-CBP Transcription FactorsArabidopsis thalianaHAC proteinsp300/CBP inhibitors

Identifiers

PMID36142359
PMCPMC9499386
OpenAlexW4296804388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.