Evidence map›Paper›PMID 36142334›Full record

ArticleInternational journal of molecular sciences2022

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Accelerate Diabetic Wound Healing via Promoting M2 Macrophage Polarization, Angiogenesis, and Collagen Deposition.

Liping Teng, Maria Maqsood, Min Zhu, Yuting Zhou, Mingzhu Kang, Juan Zhou, Jinghua Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 3 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  6. Review
  7. Article
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  13. Article
  14. Exosomal peptides and proteins in wound healing and skin regeneration.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  15. Article
  16. Article
  17. Exosome-Based Therapies in Dermatology.Aesthetic plastic surgery · 2025
    Review
  18. Article
  19. Review
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Liping TengWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Maria MaqsoodSchool of Life Sciences and Heath Engineering, Jiangnan University, Wuxi 214122, China.
Min ZhuWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Yuting ZhouSchool of Life Sciences and Heath Engineering, Jiangnan University, Wuxi 214122, China.
Mingzhu KangSchool of Life Sciences and Heath Engineering, Jiangnan University, Wuxi 214122, China.
Juan ZhouSchool of Life Sciences and Heath Engineering, Jiangnan University, Wuxi 214122, China.ORCID 0000-0001-9770-7229
Jinghua ChenSchool of Life Sciences and Heath Engineering, Jiangnan University, Wuxi 214122, China.
Jiangnan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some scholars have suggested that the clinical application of exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs-exo) might represent a novel strategy to improve diabetic wound healing. However, the mechanisms underlying the effects of hucMSCs-exo on wound healing remain poorly understood. This study aimed to identify the mechanism of hucMSCs-exo in treating diabetic wounds. HucMSCs-exo were isolated from human umbilical cord mesenchymal stem cells (hucMSCs) and subcutaneously injected into full-thickness wounds in diabetic rats. Wound healing closure rates and histological analysis were performed. The levels of tumor necrosis factor-α (TNF-α), macrophage mannose receptor (MMR/CD206), platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31), and vascular endothelial growth factor (VEGF) were detected by immunohistochemistry. The degree of collagen deposition was examined using Masson's trichrome staining. Gross evaluation of wound healing was carried out from day 0 to 14 post-surgery, and the wound site was harvested for histology on days 3, 7, and 14 post-wounding. HucMSCs-exo transplantation increased diabetic wound healing. In vitro, hucMSCs-exo promoted the proliferation of human umbilical vein endothelial cells (HUVECs) and NIH-3T3 cells. In vivo, hucMSCs-exo reduced wound area and inflammatory infiltration and increased collagen fibers. In addition, wound tissues in the hucMSCs-exo group had higher CD206, CD31, and VEGF expressions and lower TNF-α levels than those in the control group on day 14. Our results demonstrated that hucMSCs-exo facilitated diabetic wound repair by inducing anti-inflammatory macrophages and promoting angiogenesis and collagen deposition.

Indexed as

Diabetes Mellitus, ExperimentalExosomesMesenchymal Stem CellsAnimalsCollagenHumansHuman Umbilical Vein Endothelial CellsMacrophagesMiceNeovascularization, PathologicPlatelet Endothelial Cell Adhesion Molecule-1RatsTumor Necrosis Factor-alphaUmbilical CordVascular Endothelial Growth Factor AWound HealingCollagenPlatelet Endothelial Cell Adhesion Molecule-1Tumor Necrosis Factor-alphaVascular Endothelial Growth Factor Adiabetesexosomeshuman-umbilical-cord-derived mesenchymal stem cellsmacrophage polarizationwound healing

Identifiers

PMID36142334
PMCPMC9498995
OpenAlexW4295213612

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.