Evidence map›Paper›PMID 36142326›Full record

ArticleInternational journal of molecular sciences2022

Allyl Isothiocyanate (AITC) Induces Apoptotic Cell Death In Vitro and Exhibits Anti-Tumor Activity in a Human Glioblastoma GBM8401/

Kung-Wen Lu, Tai-Jung Lu, Fu-Shin Chueh, Kuang-Chi Lai, Te-Chun Hsia, Shu-Fen Peng, Ching-Chang Cheng, Yu-Cheng Chou, Fei-Ting Hsu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kung-Wen LuCollege of Chinese Medicine, School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung 404, Taiwan.
Tai-Jung LuDepartment of Biological Science and Technology, China Medical University, Taichung 404, Taiwan.
Fu-Shin ChuehDepartment of Food Nutrition and Health Biotechnology, Asia University, Taichung 413, Taiwan.
Kuang-Chi LaiDepartment of Medical Laboratory Science and Biotechnology, College of Medical Technology, Chung Hwa University of Medical Technology, Tainan 717, Taiwan.
Te-Chun HsiaDepartment of Respiratory Therapy, China Medical University, Taichung 404, Taiwan.
Shu-Fen PengDepartment of Medical Research, China Medical University Hospital, Taichung 404, Taiwan.
Ching-Chang ChengDirector of Laboratory Animal Service Center, Office of Research and Development, China Medical University, Taichung 404, Taiwan.
Yu-Cheng ChouDepartment of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung 407, Taiwan.
Fei-Ting HsuDepartment of Biological Science and Technology, China Medical University, Taichung 404, Taiwan.
China Medical University · TWAsia University · TWNational Chi Nan University · TW

Funding

China Medical University CMU107-TU-05Experiments and data analysis were performed in part through the use of the Medical Research Core Facilities Center, Office of Research & Development at China Medical University, Taichung, Taiwan, ROC. N/A
6 · The paper itself

Abstract

Some clinically used anti-cancer drugs are obtained from natural products. Allyl isothiocyanate (AITC), a plant-derived compound abundant in cruciferous vegetables, has been shown to possess an anti-cancer ability in human cancer cell lines in vitro, including human brain glioma cells. However, the anti-cancer effects of AITC in human glioblastoma (GBM) cells in vivo have not yet been examined. In the present study, we used GBM8401/

Indexed as

Antineoplastic AgentsBiological ProductsGlioblastomaGliomaAnimalsApoptosisbcl-2-Associated X ProteinCaspase 3Cell Line, TumorCell ProliferationIsothiocyanatesMatrix Metalloproteinase 9MiceMice, NudeMyeloid Cell Leukemia Sequence 1 ProteinPhytochemicals2,3,4-tri-O-acetylarabinopyranosyl isothiocyanateallyl isothiocyanateAntineoplastic Agentsbcl-2-Associated X ProteinBiological ProductsCaspase 3IsothiocyanatesMatrix Metalloproteinase 9Myeloid Cell Leukemia Sequence 1 ProteinPhytochemicalsProto-Oncogene Proteins c-bcl-2Vascular Endothelial Growth Factor AAITCapoptosiscaspaseglioblastoma GBM8401/luc2 cancer cellsxenograft

Identifiers

PMID36142326
PMCPMC9499574
OpenAlexW4295213560

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.