Evidence map›Paper›PMID 36142296›Full record

ArticleInternational journal of molecular sciences2022

Serum Phospholipid Profile Changes in Gaucher Disease and Parkinson's Disease.

Laura López de Frutos, Francisco Almeida, Jessica Murillo-Saich, Vasco A Conceição, Monica Guma, Oswald Queheberger, Pilar Giraldo, Gabriel Miltenberger-Miltenyi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. p.N370SInternational journal of molecular sciences · 2025
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  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Deciphering metabolic shifts in Gaucher disease type 1: a multi-omics study.Journal of molecular medicine (Berlin, Germany) · 2025
    Article
  10. Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Laura López de FrutosFundación para el Estudio y la Terapéutica de la Enfermedad de Gaucher y Otras Lisosomales (FEETEG), 50006 Zaragoza, Spain.ORCID 0000-0002-1369-6225
Francisco AlmeidaInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649004 Lisbon, Portugal.
Jessica Murillo-SaichDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Vasco A ConceiçãoInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649004 Lisbon, Portugal.ORCID 0000-0003-2281-5748
Monica GumaDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Oswald QuehebergerDepartment of Pharmacology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Pilar GiraldoFundación para el Estudio y la Terapéutica de la Enfermedad de Gaucher y Otras Lisosomales (FEETEG), 50006 Zaragoza, Spain.ORCID 0000-0002-8791-1901
Gabriel Miltenberger-MiltenyiInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649004 Lisbon, Portugal.
University of Lisbon · PTUniversity of California San Diego · USHospital Universitario Miguel Servet · ESUniversitat Autònoma de Barcelona · ES

Funding

Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
Targeting hexokinase-2 in rheumatoid arthritisR01AR073324 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUMA, MONICA · 2018 to 2022
$2.4M
NIAMS NIH HHS R01 AR073324NIAMS NIH HHS T32 AR064194Sanofi (Portugal) SZG-2018-11992
6 · The paper itself

Abstract

Alterations in the levels of serum sphingolipids and phospholipids have been reported in Gaucher disease and in Parkinson's disease, suggesting a potential role of these lipids as biomarkers. This project's objective is to detect novel associations and novel candidate biomarkers in the largest Spanish Gaucher and Parkinson diseases of the Iberian Peninsula. For that, 278 participants were included: 100 sporadic Parkinson's patients, 70 Gaucher patients, 15

Indexed as

Gaucher DiseaseParkinson Disease1-DeoxynojirimycinBiomarkersDopamine AgonistsHumansMutationPhosphatidylcholinesPhosphatidylethanolaminesPhosphatidylglycerolsPhosphatidylserinesPlasmalogensSphingolipids1-DeoxynojirimycinBiomarkersDopamine AgonistsmiglustatPhosphatidylcholinesPhosphatidylethanolaminesPhosphatidylglycerolsPhosphatidylserinesPlasmalogensSphingolipidsdopamine agonistGaucher diseaseGBA1miglustatParkinson’s diseaseplasma phospholipids

Identifiers

PMID36142296
PMCPMC9499334
OpenAlexW4296117385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.