Evidence map›Paper›PMID 36142287›Full record

ArticleInternational journal of molecular sciences2022

The Antiarrhythmic and Hypotensive Effects of S-61 and S-73, the Pyrrolidin-2-one Derivatives with α

Klaudia Lustyk, Kinga Sałaciak, Agata Siwek, Jacek Sapa, Paula Zaręba, Adam Gałuszka, Karolina Pytka

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Novel Arylpiperazine Derivatives of Salicylamide with αInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Klaudia LustykDepartment of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Kinga SałaciakDepartment of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.ORCID 0000-0002-0507-1989
Agata SiwekDepartment of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Jacek SapaDepartment of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Paula ZarębaDepartment of Physiochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Adam GałuszkaDepartment of Automatic Control and Robotics, Silesian University of Technology, Akademicka 2A, 44-100 Gliwice, Poland.ORCID 0000-0002-6176-0500
Karolina PytkaDepartment of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.ORCID 0000-0001-7134-9515
Jagiellonian University · PLSilesian University of Technology · PL

Funding

Jagiellonian University K/DSC/003508RGP 02/060/RGP20/0019Silesian University of Technology 02/060/BK_22/0030
6 · The paper itself

Abstract

Heart rhythm abnormalities are a cause of many deaths worldwide. Unfortunately, the available antiarrhythmic drugs show limited efficacy and proarrhythmic potential. Thus, efforts should be made to search for new, more effective, and safer pharmacotherapies. Several studies suggested that blocking the α

Indexed as

Anti-Arrhythmia AgentsAntihypertensive AgentsAconitineAdrenergic AntagonistsAnimalsArrhythmias, CardiacCalcium ChlorideEpinephrineMethoxaminePyrrolidinonesRatsRats, WistarReceptors, Adrenergic, alpha-1Receptors, Adrenergic, beta-1AconitineAdrenergic AntagonistsAnti-Arrhythmia AgentsAntihypertensive AgentsCalcium ChlorideEpinephrineMethoxaminePyrrolidinonesReceptors, Adrenergic, alpha-1Receptors, Adrenergic, beta-1adrenaline-induced arrhythmiaalpha-1 adrenergic receptoralpha-1 adrenolyticsarrhythmiapyrrolidin-2-one

Identifiers

PMID36142287
PMCPMC9499458
OpenAlexW4296117580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.