ArticleInternational journal of molecular sciences2022
Effect of Different Molecular Weights of Polyacrylic Acid on Rat Lung Following Intratracheal Instillation.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Polyacrylic acid, but not polyethylene glycol, induces metabolic reprogramming linked to pulmonary fibrosis in rats.Scientific reports · 2025Article
- The degree of cross-linking of polyacrylic acid affects the fibrogenicity in rat lungs.Scientific reports · 2025Article
- Adverse effects of nanoparticles on humans.Journal of occupational health · 2025Review
- Development of a new alternative method to inhalation exposure: intratracheal instillation studies using molecular dispersion.Environmental health and preventive medicine · 2025Article
- The Effects of Endoplasmic Reticulum Stress via Intratracheal Instillation of Water-Soluble Acrylic Acid Polymer on the Lungs of Rats.International journal of molecular sciences · 2024Article
- Cell-Material Interactions 2022.International journal of molecular sciences · 2023Article
- Crosslinked Structure of Polyacrylic Acid Affects Pulmonary Fibrogenicity in Rats.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWe conducted intratracheal instillations of different molecular weights of polyacrylic acid (PAA) into rats in order to examine what kinds of physicochemical characteristics of acrylic acid-based polymer affect responses in the lung.
methodsF344 rats were intratracheally exposed to a high molecular weight (HMW) of 598 thousand g/mol or a low molecular weight (LMW) of 30.9 thousand g/mol PAA at low and high doses. Rats were sacrificed at 3 days, 1 week, 1 month, 3 months and 6 months post exposure.
resultsHMW PAA caused persistent increases in neutrophil influx, cytokine-induced neutrophil chemoattractants (CINC) in the bronchoalveolar lavage fluid (BALF), and heme oxygenase-1 (HO-1) in the lung tissue from 3 days to 3 months and 6 months following instillation. On the other hand, LMW PAA caused only transient increases in neutrophil influx, CINC in BALF, and HO-1 in the lung tissue from 3 days to up to 1 week or 1 month following instillation. Histopathological findings of the lungs demonstrated that the extensive inflammation and fibrotic changes caused by the HMW PAA was greater than that in exposure to the LMW PAA during the observation period.
conclusionHMW PAA induced persistence of lung disorder, suggesting that molecular weight is a physicochemical characteristic of PAA-induced lung disorder.
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Registered trials
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