Evidence map›Paper›PMID 36142238›Full record

ReviewInternational journal of molecular sciences2022

Extraction of High-Value Chemicals from Plants for Technical and Medical Applications.

Pritam Kapadia, Amy S Newell, John Cunningham, Michael R Roberts, John G Hardy

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 93 citations in OpenAlex.

  1. Steviol Glycosides (E960) FromFood science & nutrition · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. A deep dive into herbal extraction: Techniques, trends, and technological advancements.South African journal of botany : official journal of the South African Association of Botanists = Suid-Afrikaanse tydskrif vir plantkunde : amptelike tydskrif van die Suid-Afrikaanse Genootskap van Plantkundiges · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Chemical Profile ofPlants (Basel, Switzerland) · 2024
    Article
  17. Article
  18. Article
  19. Unraveling current breakthroughs inBiotechnology notes (Amsterdam, Netherlands) · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pritam KapadiaDepartment of Chemistry, Lancaster University, Lancaster LA1 4YB, UK.
Amy S NewellDepartment of Chemistry, Lancaster University, Lancaster LA1 4YB, UK.ORCID 0000-0002-2389-9210
John CunninghamCO2 Extraction Ltd., 7 Stevant Way, Northgate, Morecambe LA3 3PU, UK.
Michael R RobertsLancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, UK.ORCID 0000-0002-1441-7363
John G HardyDepartment of Chemistry, Lancaster University, Lancaster LA1 4YB, UK.ORCID 0000-0003-0655-2167
Lancaster University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plants produce a variety of high-value chemicals (e.g., secondary metabolites) which have a plethora of biological activities, which may be utilised in many facets of industry (e.g., agrisciences, cosmetics, drugs, neutraceuticals, household products, etc.). Exposure to various different environments, as well as their treatment (e.g., exposure to chemicals), can influence the chemical makeup of these plants and, in turn, which chemicals will be prevalent within them. Essential oils (EOs) usually have complex compositions (>300 organic compounds, e.g., alkaloids, flavonoids, phenolic acids, saponins and terpenes) and are obtained from botanically defined plant raw materials by dry/steam distillation or a suitable mechanical process (without heating). In certain cases, an antioxidant may be added to the EO (EOs are produced by more than 17,500 species of plants, but only ca. 250 EOs are commercially available). The interesting bioactivity of the chemicals produced by plants renders them high in value, motivating investment in their production, extraction and analysis. Traditional methods for effectively extracting plant-derived biomolecules include cold pressing and hydro/steam distillation; newer methods include solvent/Soxhlet extractions and sustainable processes that reduce waste, decrease processing times and deliver competitive yields, examples of which include microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), subcritical water extraction (SWE) and supercritical CO2 extraction (scCO2). Once extracted, analytical techniques such as chromatography and mass spectrometry may be used to analyse the contents of the high-value extracts within a given feedstock. The bioactive components, which can be used in a variety of formulations and products (e.g., displaying anti-aging, antibacterial, anticancer, anti-depressive, antifungal, anti-inflammatory, antioxidant, antiparasitic, antiviral and anti-stress properties), are biorenewable high-value chemicals.

Indexed as

Oils, VolatileSaponinsAnti-Bacterial AgentsAntifungal AgentsAntioxidantsAntiparasitic AgentsAntiviral AgentsCarbon DioxideFlavonoidsPlant ExtractsPlantsSolventsSteamTerpenesAnti-Bacterial AgentsAntifungal AgentsAntioxidantsAntiparasitic AgentsAntiviral AgentsCarbon DioxideFlavonoidsOils, VolatilePlant ExtractsSaponinsSolventsSteamTerpenesapplicationsbiomoleculesessential oilsextraction methodshigh-value chemicalssecondary metabolites

Identifiers

PMID36142238
PMCPMC9499410
OpenAlexW4296086634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.