Evidence map›Paper›PMID 36142230›Full record

ArticleInternational journal of molecular sciences2022

Phenanthroindolizidine Alkaloids Isolated from

Irene Reimche, Haiqian Yu, Ni Putu Ariantari, Zhen Liu, Kay Merkens, Stella Rotfuß, Karin Peter, Ute Jungwirth, Nadine Bauer, Friedemann Kiefer and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Genetically Encoded Reporters to Monitor Hypoxia.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  6. Article
  7. Mechanisms of Phytochemicals in Anti-Inflammatory and Anti-Cancer.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Irene ReimcheDepartment of Biomedical Sciences, Institute of Health Research and Education, University of Osnabrück, 49090 Osnabrück, Germany.ORCID 0000-0001-8027-7672
Haiqian YuInstitute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany.
Ni Putu AriantariInstitute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany.
Zhen LiuInstitute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany.
Kay MerkensDepartment of Chemistry, University of Cologne, 50923 Cologne, Germany.ORCID 0000-0003-0753-2117
Stella RotfußDepartment of Biomedical Sciences, Institute of Health Research and Education, University of Osnabrück, 49090 Osnabrück, Germany.
Karin PeterDepartment of Biomedical Sciences, Institute of Health Research and Education, University of Osnabrück, 49090 Osnabrück, Germany.ORCID 0000-0003-3775-9195
Ute JungwirthDepartment of Life Sciences, Centre for Therapeutic Innovation, University of Bath, Bath BA2 7AY, UK.ORCID 0000-0002-4673-3096
Nadine BauerEuropean Institute of Molecular Imaging, University of Münster, 48149 Münster, Germany.ORCID 0000-0002-4483-4205
Friedemann KieferEuropean Institute of Molecular Imaging, University of Münster, 48149 Münster, Germany.
Jörg-Martin NeudörflDepartment of Chemistry, University of Cologne, 50923 Cologne, Germany.
Hans-Günther SchmalzDepartment of Chemistry, University of Cologne, 50923 Cologne, Germany.ORCID 0000-0003-0489-1827
Peter ProkschInstitute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany.
Nicole TeuschDepartment of Biomedical Sciences, Institute of Health Research and Education, University of Osnabrück, 49090 Osnabrück, Germany.ORCID 0000-0002-9030-1493
Osnabrück University · DEHeinrich Heine University Düsseldorf · DEUniversity of Cologne · DEUniversity of Münster · DEUdayana University · IDUniversity of Bath · GB

Funding

Deutsche Forschungsgemeinschaft EXC1003-194347757Deutsche Forschungsgemeinschaft GRK 2158; 270650915Deutsche Forschungsgemeinschaft SFB1450/1-431460824
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC), representing the most aggressive form of breast cancer with currently no targeted therapy available, is characterized by an inflammatory and hypoxic tumor microenvironment. To date, a broad spectrum of anti-tumor activities has been reported for phenanthroindolizidine alkaloids (PAs), however, their mode of action in TNBC remains elusive. Thus, we investigated six naturally occurring PAs extracted from the plant

Indexed as

AlkaloidsTriple Negative Breast NeoplasmsAnimalsCell Line, TumorCell ProliferationCollagen Type IHumansIndole AlkaloidsIndolizinesInflammationMiceNF-kappa BNF-KappaB Inhibitor alphaPaclitaxelPhenanthrenesPhenanthrolinesAlkaloidsCollagen Type IIndole AlkaloidsIndolizinesNF-kappa BNF-KappaB Inhibitor alphaO-methyltylophorinidinePaclitaxelPhenanthrenesphenanthroindolizidinePhenanthrolines3D spheroidcancer-associated fibroblast (CAF)hypoxia-inducible factor (HIF)nuclear factor kappa B (NFκB)O-methyltylophorinidinephenanthroindolizidine alkaloidstriple-negative breast cancer (TNBC)tumor microenvironment (TME)

Identifiers

PMID36142230
PMCPMC9499467
OpenAlexW4296807992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.