ArticleInternational journal of molecular sciences2022
Indications of Peripheral Pain, Dermal Hypersensitivity, and Neurogenic Inflammation in Patients with Lipedema.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06770634 (Investigation of the Prevalence of Central Sensitization and Associated Factors in Patients With Lipedema), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of the Prevalence of Central Sensitization and Associated Factors in Patients With Lipedema
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Lipedema: Progress, Challenges, and the Road Ahead.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Changes in plasma fatty acid composition in females with lipedema following low-carbohydrate vs low-fat diets and associations with pain reduction.Nutrition journal · 2026Trial
- Trial
- Inter-Rater Reliability of the Progressive Pain Check Method for Standardized Pain Assessment in Lipedema.Life (Basel, Switzerland) · 2026Article
- Molecular Distinctions, Diagnosis, and Mechanism-Based Therapies in Lipedema and Obesity.Current issues in molecular biology · 2026Review
- Article
- Central Sensitization, Pain, and Psychosocial Factors in Individuals with Lipedema: A Cross-Sectional Study.Aesthetic plastic surgery · 2026Article
- From Endometriosis to Lipedema: Toward a Neuroimmune Framework for Pain Amplification in Hormone-Sensitive Disorders.Biomedicines · 2026Review
- Lipedema Reframed: AFS Framework for Surgical and Transdisciplinary Management.Aesthetic plastic surgery · 2026Review
- Exploring quality of life and physical-physiological characteristics in obese patients with and without lipedema: insights from the LipObes study.BMC women's health · 2026Article
- Assessment of the elasticity of lipedematous tissue and the examination of the relationship between pain and fibrosis in lipedema.International journal of obesity (2005) · 2026Observational
- Comorbidities in lipedema: toward a systemic perspective - a narrative review.Clinical and experimental medicine · 2026Review
- Cutaneous Sensory Alterations After Lower Limb Liposuction for Lipedema: A Comparative Study with Aesthetic Liposuction Patients.Aesthetic plastic surgery · 2026Article
- Lipedema World Alliance Delphi Consensus-Based Position Paper on the Definition and Management of Lipedema: Results from the 2023 Lipedema World Congress in Potsdam.Nature communications · 2026Article
- Glucose and insulin dynamics following low-carbohydrate and low-fat diets in females with lipedema and obesity.Frontiers in cell and developmental biology · 2026Article
- Lipedema as a hormone-sensitive stromal disorder: a four-pathway translational framework.Frontiers in cell and developmental biology · 2026Article
- Management of lipedema with a biphasic ketogenic/low-carbohydrate diet: a case report.Frontiers in nutrition · 2026Article
- New Characterization of Lipedema Stages: Focus on Pain, Water, Fat and Skeletal Muscle.Life (Basel, Switzerland) · 2025Article
- Article
- Lipedema after Bariatric and Metabolic Surgery: A Scoping Review.Obesity surgery · 2025Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Lipedema is a disease with abnormally increased adipose tissue deposition and distribution. Pain sensations have been described in the clinical evaluation of lipedema, but its etiology remains poorly understood. We hypothesized that pain sensitivity measurements and ex vivo quantitation of neuronal cell body distribution in the skin would be lipedema stage-dependent, and could, thus, serve to objectively characterize neuropathic pain in lipedema. The pain was assessed by questionnaire and peripheral cutaneous mechanical sensitization (von-Frey) in lipedema (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.