Evidence map›Paper›PMID 36142178›Full record

ArticleInternational journal of molecular sciences2022

Orlistat Mitigates Oxidative Stress-Linked Myocardial Damage via NF-κβ- and Caspase-Dependent Activities in Obese Rats.

Zaidatul Akmal Othman, Zaida Zakaria, Joseph Bagi Suleiman, Khairul Mohd Fadzli Mustaffa, Nur Asyilla Che Jalil, Wan Syaheedah Wan Ghazali, Ninie Nadia Zulkipli, Mahaneem Mohamed

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Effect ofBiomolecules · 2025
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  5. Maturation-stage effects ofRSC advances · 2025
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  6. Article
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  8. Role ofAntioxidants (Basel, Switzerland) · 2024
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Zaidatul Akmal OthmanUnit of Physiology, Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu 20400, Terengganu, Malaysia.
Zaida ZakariaDepartment of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.ORCID 0000-0002-4138-4747
Joseph Bagi SuleimanDepartment of Science Laboratory Technology, Akanu Ibiam Federal Polytechnic, Unwana P.M.B. 1007, Afikpo, Ebonyi State, Nigeria.ORCID 0000-0002-0629-7621
Khairul Mohd Fadzli MustaffaInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.ORCID 0000-0002-9422-005X
Nur Asyilla Che JalilDepartment of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.
Wan Syaheedah Wan GhazaliDepartment of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.
Ninie Nadia ZulkipliDepartment of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.ORCID 0000-0002-5613-4919
Mahaneem MohamedDepartment of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.ORCID 0000-0001-9333-1957
Universiti Sains Malaysia · MYThe Federal Polytechnic, Ado-Ekiti · NG

Funding

Universiti Sains Malaysia 1001.PPSP.8012378
6 · The paper itself

Abstract

Oxidative stress contributes to major complications of obesity. This study intended to identify whether orlistat could mitigate myocardial damage in obese animal models. The tested rats were divided into two groups and fed either with normal chow (

Indexed as

AntioxidantsNF-E2-Related Factor 2AnimalsApoptosisbcl-2-Associated X ProteinCaspase 3Caspase 8Caspase 9Diet, High-FatInflammationObesityOrlistatOxidative StressRatsRNA, MessengerSuperoxide DismutaseAntioxidantsbcl-2-Associated X ProteinCaspase 3Caspase 8Caspase 9NF-E2-Related Factor 2OrlistatRNA, MessengerSuperoxide DismutaseThiobarbituric Acid Reactive SubstancesTumor Necrosis Factor-alphaWaterapoptosisinflammationobesityorlistatoxidative stress

Identifiers

PMID36142178
PMCPMC9499462
OpenAlexW4296795166

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.