Evidence map›Paper›PMID 36142154›Full record

ArticleInternational journal of molecular sciences2022

Optical Activation of TrkB (E281A) in Excitatory and Inhibitory Neurons of the Mouse Visual Cortex.

Antonia Lilja, Giuliano Didio, Jongryul Hong, Won Do Heo, Eero Castrén, Juzoh Umemori

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Light-Controlled Modulation and Analysis of Neuronal Functions.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Antonia LiljaFaculty of Psychology and Neuroscience, Maastricht University, 6229 ER Maastricht, The Netherlands.
Giuliano DidioNeuroscience Center, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, 00100 Helsinki, Finland.
Jongryul HongDepartment of Biological Science, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.
Won Do HeoDepartment of Biological Science, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.
Eero CastrénNeuroscience Center, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, 00100 Helsinki, Finland.ORCID 0000-0002-1402-2791
Juzoh UmemoriNeuroscience Center, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, 00100 Helsinki, Finland.ORCID 0000-0003-2595-7362
University of Helsinki · FIKorea Advanced Institute of Science and Technology · KR

Funding

Bilateral exchange program between Academy of Finland and JSPS (Japan Society for the Promotion of Science). N/AERC grant - iPLASTICITY 322742Jane and Aatos Erkko Foundation 327192Neurodegenerative Disease Research (JPND) CircProt project co-funded by EU and Academy of Finland 643417Sigrid Jusélius Foundation 307416
6 · The paper itself

Abstract

The activation of tropomyosin receptor kinase B (TrkB), the receptor of brain-derived neurotrophic factor (BDNF), plays a key role in induced juvenile-like plasticity (iPlasticity), which allows restructuring of neural networks in adulthood. Optically activatable TrkB (optoTrkB) can temporarily and spatially evoke iPlasticity, and recently, optoTrkB (E281A) was developed as a variant that is highly sensitive to light stimulation while having lower basal activity compared to the original optoTrkB. In this study, we validate optoTrkB (E281A) activated in alpha calcium/calmodulin-dependent protein kinase type II positive (CKII

Indexed as

Brain-Derived Neurotrophic FactorVisual CortexAnimalsCalciumMiceNeuronsParvalbuminsReceptor, trkBTropomyosinBrain-Derived Neurotrophic FactorCalciumParvalbuminsReceptor, trkBTropomyosincalcium/calmodulin positive pyramidal neuronsmultiple regression with interaction and simple slopes analysisneural plasticityparvalbumin-positive interneuronstropomyosin kinase receptor BV1/visual cortex

Identifiers

PMID36142154
PMCPMC9499497
OpenAlexW4294930662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.