Evidence map›Paper›PMID 36142117›Full record

ArticleInternational journal of molecular sciences2022

Down-Regulation of Double C2 Domain Alpha Promotes the Formation of Hyperplastic Nerve Fibers in Aganglionic Segments of Hirschsprung's Disease.

Jun Xiao, Xinyao Meng, Ke Chen, Jing Wang, Luyao Wu, Yingjian Chen, Xiaosi Yu, Jiexiong Feng, Zhi Li

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Integrative multi-omics identifiesPsychological medicine · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jun XiaoDepartment of Pediatric Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.
Xinyao MengDepartment of Pediatric Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.
Ke ChenDepartment of Pediatric Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.
Jing WangDepartment of Pediatric Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.
Luyao WuDepartment of Pediatric Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.
Yingjian ChenDepartment of Pediatric Surgery, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China.ORCID 0000-0002-0015-4371
Xiaosi YuDepartment of Pediatric Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.
Jiexiong FengDepartment of Pediatric Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhi LiDepartment of Pediatric Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0000-0002-2669-179X
Hubei Provincial Center for Disease Control and Prevention · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hirschsprung's disease (HSCR) is a common developmental anomaly of the gastrointestinal tract in children. The most significant characteristics of aganglionic segments in HSCR are hyperplastic extrinsic nerve fibers and the absence of endogenous ganglion plexus. Double C2 domain alpha (DOC2A) is mainly located in the nucleus and is involved in Ca

Indexed as

Hirschsprung DiseaseAnimalsC2 DomainsColonDown-RegulationNerve FibersNeurotransmitter AgentsRNA, MessengerZebrafishNeurotransmitter AgentsRNA, MessengerDOC2AHirschsprung diseasehyperplastic nerve fibersneural spherezebrafish

Identifiers

PMID36142117
PMCPMC9499397
OpenAlexW4294733788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.