Evidence map›Paper›PMID 36141386›Full record

ArticleHealthcare (Basel, Switzerland)2022

Maria-do-Céu Monteiro, Alberto C P Dias, Daniela Costa, António Almeida-Dias, Maria Begoña Criado

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Healthcare (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. The Putative Antidiabetic Effect ofInternational journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Maria-do-Céu MonteiroTOXRUN-CESPU Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra, Portugal.ORCID 0000-0001-9719-9746
Alberto C P DiasCITAB-UM-Centre for the Research and Technology of Agro-Environmental and Biological Sciences, Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal.
Daniela CostaCITAB-UM-Centre for the Research and Technology of Agro-Environmental and Biological Sciences, Department of Biology, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal.
António Almeida-DiasIA &HEALTH-CESPU Research Unit in Artificial Intelligence and Health, CESPU, CRL, 4585-116 Gandra, Portugal.
Maria Begoña CriadoTOXRUN-CESPU Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra, Portugal.ORCID 0000-0003-1750-5614
Cooperativa de Ensino Superior Politécnico e Universitário · PTUniversity of Minho · PT

Funding

Cooperativa de Ensino Superior Politécnico e Universitário grant number PAEHP_CESPU_2017.
6 · The paper itself

Abstract

background

methodsWe characterized the profile of platelet activation in the presence of HP extracts through an evaluation of molecular markers by flow cytometry: mobilization of intracellular Ca++ and expression of platelet receptors such as activated GPIIbIIIa and P-selectin (CD62).

resultsThe results indicated a possible inhibitory effect of HP on the platelet activation response, which could be explained by the effect on intracellular calcium mobilization and the expression of activated GPIIbIIIa receptors. Despite of the limitations of an in vitro study, our results provide evidence of the possible mechanisms of action of HP.

conclusionsFurther studies are needed to elucidate the effect of HP on hemostasis, but it may be recognized as a substance with antiplatelet properties.

Indexed as

flow cytometryHypericum perforatumplatelet activationtraditional Chinese medicine

Identifiers

PMID36141386
PMCPMC9498564
OpenAlexW4296049827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.