Evidence map›Paper›PMID 36141326›Full record

ArticleHealthcare (Basel, Switzerland)2022

Accelerating the Development and Validation of Liquid Biopsy for Early Cancer Screening and Treatment Tailoring.

Denis Horgan, Tanja Čufer, Francesco Gatto, Iwona Lugowska, Donatella Verbanac, Ângela Carvalho, Jonathan A Lal, Marta Kozaric, Sinead Toomey, Hristo Y Ivanov and 5 more

Abstract read
In one paragraph

Article in Healthcare (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
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  4. Circulating-free DNA: A promising tool for early detection of myocardial infarction.International journal of cardiology. Cardiovascular risk and prevention · 2025
    Review
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  6. Article
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  11. Article
  12. Article
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  14. Article
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  16. Review
  17. Article
  18. Article
  19. The Impact of Liquid Biopsies Positive forDiagnostics (Basel, Switzerland) · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Denis HorganEuropean Alliance for Personalised Medicine, 1040 Brussels, Belgium.
Tanja ČuferMedical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.
Francesco GattoDepartment of Oncology-Pathology, Karolinska Institute, 171 64 Stockholm, Sweden.ORCID 0000-0002-9031-9562
Iwona LugowskaDepartment of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute and Oncology Centre (MSCI), 02781 Warsaw, Poland.ORCID 0000-0001-9511-178X
Donatella VerbanacDepartment of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000 Zagreb, Croatia.ORCID 0000-0002-9106-1604
Ângela Carvalhoi3S-nstituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.ORCID 0000-0002-4837-6539
Jonathan A LalDepartment of Molecular and Cellular Engineering, Jacob Institute of Biotechnology and Bioengineering, Faculty of Engineering and Technology, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj 211007, India.
Marta KozaricEuropean Alliance for Personalised Medicine, 1040 Brussels, Belgium.
Sinead ToomeyDepartment of Molecular Medicine, RCSI University of Medicine and Health Sciences, Beaumont Hospital, Smurfit Building, D09 Dublin, Ireland.
Hristo Y IvanovDepartment of Paediatric and Medical Genetics, Medical University, 4000 Plovdiv, Bulgaria.
John LongshoreAstra Zeneca, 1800 Concord Pike, Wilmington, DE 19803, USA.
Umberto MalapelleDepartment of Public Health, University of Naples Federico II, 80137 Naples, Italy.ORCID 0000-0003-3211-9957
Samantha HasenleithnerInstitute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-9401-5224
Paul HofmanLaboratory of Clinical and Experimental Pathology, FHU OncoAge, Pasteur Hospital, University Côte d'Azur, CEDEX 01, 06001 Nice, France.ORCID 0000-0003-0431-9353
Catherine Alix-PanabièresLaboratory of Rare Human Circulating Cells (LCCRH), University Medical Centre of Montpellier, 641 Avenue du Doyen Gaston Giraud, CEDEX 5, 34093 Montpellier, France.ORCID 0000-0002-6401-2903

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liquid biopsy (LB) is a minimally invasive method which aims to detect circulating tumor-derived components in body fluids. It provides an alternative to current cancer screening methods that use tissue biopsies for the confirmation of diagnosis. This paper attempts to determine how far the regulatory, policy, and governance framework provide support to LB implementation into healthcare systems and how the situation can be improved. For that reason, the European Alliance for Personalised Medicine (EAPM) organized series of expert panels including different key stakeholders to identify different steps, challenges, and opportunities that need to be taken to effectively implement LB technology at the country level across Europe. To accomplish a change of patient care with an LB approach, it is required to establish collaboration between multiple stakeholders, including payers, policymakers, the medical and scientific community, and patient organizations, both at the national and international level. Regulators, pharma companies, and payers could have a major impact in their own domain. Linking national efforts to EU efforts and vice versa could help in implementation of LB across Europe, while patients, scientists, physicians, and kit manufacturers can generate a pull by undertaking more research into biomarkers.

Indexed as

cancerdiagnosisgovernancehealthcareimplementationlegislationliquid biopsypersonalized medicinepolicy frameworktechnologytreatment

Identifiers

PMID36141326
PMCPMC9498805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.