Evidence map›Paper›PMID 36141103›Full record

ArticleEntropy (Basel, Switzerland)2022

A New Model of Hemoglobin Oxygenation.

Igor A Lavrinenko, Gennady A Vashanov, José L Hernández Cáceres, Anatoly S Buchelnikov, Yury D Nechipurenko

Abstract read
In one paragraph

Article in Entropy (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Effect of Hb conformational changes on oxygen transport physiology.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Igor A LavrinenkoDepartment of Human and Animal Physiology, Voronezh State University, Universitetskaya Sq. 1, 394018 Voronezh, Russia.ORCID 0000-0002-2570-7331
Gennady A VashanovDepartment of Human and Animal Physiology, Voronezh State University, Universitetskaya Sq. 1, 394018 Voronezh, Russia.
José L Hernández CáceresCuban Neuroscience Center, 15202 Avenida 25, Playa, La Habana 11600, Cuba.ORCID 0000-0002-4406-444X
Anatoly S BuchelnikovLaboratory of Molecular and Cellular Biophysics, Sevastopol State University, Universitetskaya Str. 33, 299053 Sevastopol, Russia.ORCID 0000-0002-1853-4671
Yury D NechipurenkoLaboratory of DNA-Protein Interactions, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Str. 32, 119991 Moscow, Russia.ORCID 0000-0002-6976-1655

Funding

Program of Fundamental Research in the Russian Federation for 2021-2030 period project No. 121052600299-1
6 · The paper itself

Abstract

The study of hemoglobin oxygenation, starting from the classical works of Hill, has laid the foundation for molecular biophysics. The cooperative nature of oxygen binding to hemoglobin has been variously described in different models. In the Adair model, which better fits the experimental data, the constants of oxygen binding at various stages differ. However, the physical meaning of the parameters in this model remains unclear. In this work, we applied Hill's approach, extending its interpretation; we obtained a good agreement between the theory and the experiment. The equation in which the Hill coefficient is modulated by the Lorentz distribution for oxygen partial pressure approximates the experimental data better than not only the classical Hill equation, but also the Adair equation.

Indexed as

allosteric interactionscooperative binding of ligandsHill coefficientHill equationoxyhemoglobin dissociation curve

Identifiers

PMID36141103
PMCPMC9498255

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.