Evidence map›Paper›PMID 36140900›Full record

ReviewFoods (Basel, Switzerland)2022

Evidence for Quercetin as a Dietary Supplement for the Treatment of Cardio-Metabolic Diseases in Pregnancy: A Review in Rodent Models.

Paulo César Trindade da Costa, Evandro Leite de Souza, Diego Cabral Lacerda, José Patrocínio Ribeiro Cruz Neto, Ludmilla Christine Silva de Sales, Cristiane Cosmo Silva Luis, Paula Brielle Pontes, Marinaldo Pacífico Cavalcanti Neto, José Luiz de Brito Alves

Open access · goldAbstract readReview
In one paragraph

Review in Foods (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Impact of aFoods (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Paulo César Trindade da CostaPostgraduation Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, Brazil.ORCID 0000-0003-3273-2399
Evandro Leite de SouzaPostgraduation Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, Brazil.ORCID 0000-0003-4927-9383
Diego Cabral LacerdaPostgraduation Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, Brazil.
José Patrocínio Ribeiro Cruz NetoPostgraduation Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, Brazil.
Ludmilla Christine Silva de SalesPostgraduation Program in Physiological Sciences, Federal University of Paraíba, João Pessoa 58051-900, Brazil.
Cristiane Cosmo Silva LuisPostgraduation Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, Brazil.ORCID 0000-0002-7551-2591
Paula Brielle PontesPostgraduation Program in Neuropsychiatry and Health Sciences Behavior, Federal University of Pernambuco, Recife 50670-901, Brazil.
Marinaldo Pacífico Cavalcanti NetoIntegrated Laboratory of Morphofunctional Sciences, Institute of Biodiversity and Sustainability (NUPEM), Federal University of Rio de Janeiro, Macaé 21941-901, Brazil.
José Luiz de Brito AlvesPostgraduation Program in Nutrition Sciences, Health Sciences Center, Federal University of Paraiba, João Pessoa 58051-900, Brazil.ORCID 0000-0003-4696-3809
Universidade Federal da Paraíba · BRUniversidade Federal de Pernambuco · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quercetin supplementation during pregnancy and lactation has been linked to a lower risk of maternal cardio-metabolic disorders such as gestational diabetes mellitus (GDM), dyslipidemia, preeclampsia, attenuation of malnutrition-related conditions, and gestational obesity in animal studies. Pre-clinical studies have shown that maternal supplementation with quercetin reduces cardio-metabolic diseases in dams and rodents' offspring, emphasizing its role in modifying phenotypic plasticity. In this sense, it could be inferred that quercetin administration during pregnancy and lactation is a viable strategy for changing cardio-metabolic parameters throughout life. Epigenetic mechanisms affecting the AMP-activated protein kinase (AMPK), nuclear factor-kappa B (NF-κB), and phosphoinositide 3-kinase (PI3 K) pathways could be associated with these changes. To highlight these discoveries, this review outlines the understanding from animal studies investigations about quercetin supplementation and its capacity to prevent or decrease maternal and offspring cardio-metabolic illnesses and associated comorbidities.

Indexed as

metabolic diseasespolyphenolspregnancy complicationsquercetin

Identifiers

PMID36140900
PMCPMC9497971
OpenAlexW4295094544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.