Evidence map›Paper›PMID 36140552›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Role of Polyamines as Biomarkers in Lymphoma Patients: A Pilot Study.

Donatella Coradduzza, Adriana Ghironi, Emanuela Azara, Nicola Culeddu, Sara Cruciani, Angelo Zinellu, Margherita Maioli, Maria Rosaria De Miglio, Serenella Medici, Claudio Fozza and 1 more

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
  4. Ferroptosis and Senescence: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  5. Article
  6. Article
  7. Role of Blood Cell Indexes in Progresses to ESRD.Indian journal of clinical biochemistry : IJCB · 2025
    Article
  8. Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Donatella CoradduzzaDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-8978-0490
Adriana GhironiDepartment of Clinical and Experimental Medicine, University of Sassari, 07100 Sassari, Italy.
Emanuela AzaraInstitute of Biomolecular Chemistry, National Research Council, 07040 Sassari, Italy.ORCID 0000-0001-9199-9398
Nicola CuledduInstitute of Biomolecular Chemistry, National Research Council, 07040 Sassari, Italy.ORCID 0000-0001-7432-6415
Sara CrucianiDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0001-8632-2577
Angelo ZinelluDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-8396-0968
Margherita MaioliDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0003-0187-4968
Maria Rosaria De MiglioDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-9393-3234
Serenella MediciDepartment of Chemistry and Pharmacy, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-4304-0251
Claudio FozzaDepartment of Clinical and Experimental Medicine, University of Sassari, 07100 Sassari, Italy.
Ciriaco CarruDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-6985-4907

Funding

Fondazione di Sardegna ailFondazione di Sardegna liltuniss far
6 · The paper itself

Abstract

Lymphomas represent a heterogeneous and widely diversified group of neoplastic diseases rising from a variety of lymphoid subsets at heterogeneous differentiation stages. These lymphoproliferative disorders lead to the clinicopathological complexity of the classification of lymphoid neoplasms, describing to date more than 40 categories of non-Hodgkin's lymphoma (NHL) and 5 categories of Hodgkin's lymphoma (HL). Inflammation has been shown to play a key role in the evolution of cancer diseases, and it might be interesting to understand their role also in the context of lymphoid neoplasms. Among circulating biomarkers, the role of polyamines belonging to the arginine and lysine metabolism is relevant. Through modern analytical methods, such as mass spectrometry (MS), we are enabled to increase knowledge and improve our understanding of cancer metabolism. In this study, high-resolution mass spectrometry was used in combination with high-performance liquid chromatography (LC-HRMS) to measure serum levels of polyamines and identify possible diagnostic circulating biomarkers, potentially allowing a more accurate assessment of the diagnostic stratification of lymphoma patients and robust comparisons between different patient groups.

Indexed as

biomarkerslymphomapolyamines

Identifiers

PMID36140552
PMCPMC9497571

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.