Evidence map›Paper›PMID 36140474›Full record

ArticleDiagnostics (Basel, Switzerland)2022

The RALE Score Versus the CT Severity Score in Invasively Ventilated COVID-19 Patients-A Retrospective Study Comparing Their Prognostic Capacities.

Christel M Valk, Claudio Zimatore, Guido Mazzinari, Charalampos Pierrakos, Chaisith Sivakorn, Jutamas Dechsanga, Salvatore Grasso, Ludo Beenen, Lieuwe D J Bos, Frederique Paulus and 2 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. IL-6 and SAA-Strong Predictors for the Outcome in COVID-19 CKD Patients.International journal of molecular sciences · 2023
    Article
  2. Article
  3. Review
  4. Article
  5. Editorial: Personalized therapy in ARDS.Frontiers in medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 5 countries.

Christel M ValkDepartment of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Amsterdam UMC, Location 'AMC', 1105 AZ Amsterdam, The Netherlands.
Claudio ZimatoreDepartment of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Amsterdam UMC, Location 'AMC', 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0002-4875-4018
Guido MazzinariDepartment of Anaesthesiology and Critical Care, Hospital Universitario y Politecnico la Fe, 46026 Valencia, Spain.
Charalampos PierrakosDepartment of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Amsterdam UMC, Location 'AMC', 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0003-2920-8350
Chaisith SivakornIntensive Care Unit, NHS Foundation Trust, University College London Hospitals, London NW1 2BU, UK.ORCID 0000-0001-5662-1058
Jutamas DechsangaDivision of Pulmonary and Critical Care, Department of Medicine, Chonburi Hospital, Chonburi 20000, Thailand.
Salvatore GrassoDepartment of Emergency and Organ Transplantation, University of Bari Aldo Moro, 70124 Bari, Italy.
Ludo BeenenDepartment of Radiology, Amsterdam UMC, Location 'AMC', 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0001-9204-1026
Lieuwe D J BosDepartment of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Amsterdam UMC, Location 'AMC', 1105 AZ Amsterdam, The Netherlands.
Frederique PaulusDepartment of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Amsterdam UMC, Location 'AMC', 1105 AZ Amsterdam, The Netherlands.
Marcus J SchultzDepartment of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Amsterdam UMC, Location 'AMC', 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0003-3969-7792
Luigi PisaniDepartment of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Amsterdam UMC, Location 'AMC', 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0001-7177-3594
Amsterdam University Medical Centers · NLMahidol University · THChonburi Hospital · THHospital Universitari i Politècnic La Fe · ESUniversity College London Hospitals NHS Foundation Trust · GBUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundQuantitative radiological scores for the extent and severity of pulmonary infiltrates based on chest radiography (CXR) and computed tomography (CT) scan are increasingly used in critically ill invasively ventilated patients. This study aimed to determine and compare the prognostic capacity of the Radiographic Assessment of Lung Edema (RALE) score and the chest CT Severity Score (CTSS) in a cohort of invasively ventilated patients with acute respiratory distress syndrome (ARDS) due to COVID-19.

methodsTwo-center retrospective observational study, including consecutive invasively ventilated COVID-19 patients. Trained scorers calculated the RALE score of first available CXR and the CTSS of the first available CT scan. The primary outcome was ICU mortality; secondary outcomes were duration of ventilation in survivors, length of stay in ICU, and hospital-, 28-, and 90-day mortality. Prognostic accuracy for ICU death was expressed using odds ratios and Area Under the Receiver Operating Characteristic curves (AUROC).

resultsA total of 82 patients were enrolled. The median RALE score (22 [15-37] vs. 26 [20-39];

conclusionsDespite poor prognostic capacity, only CTSS was associated with ICU mortality in our cohort of COVID-19 patients.

Indexed as

ARDSchest computed tomographychest imagingchest X-raycoronavirus disease 2019CT severity scoreCTSSICUmechanical ventilationRALE score

Identifiers

PMID36140474
PMCPMC9497927
OpenAlexW4293676808

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.