Evidence map›Paper›PMID 36140411›Full record

ArticleBiomedicines2022

The Role of Intraamygdaloid Oxytocin and D2 Dopamine Receptors in Reinforcement in the Valproate-Induced Autism Rat Model.

Kristóf László, Dávid Vörös, Orsolya Kiss, Bettina Réka László, Tamás Ollmann, László Péczely, Kitti Mintál, Attila Tóth, Anita Kovács, Olga Zagoracz and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Kristóf LászlóMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
Dávid VörösMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
Orsolya KissMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
Bettina Réka LászlóMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
Tamás OllmannMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
László PéczelyMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
Kitti MintálMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
Attila TóthMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
Anita KovácsMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
Olga ZagoraczMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
Erika KertesMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
Veronika KállaiMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
Beáta BertaMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
Zoltán KarádiMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
László LénárdMedical School, Institute of Physiology, University of Pécs, Szigeti Str. 12, P.O. Box 99, 7602 Pécs, Hungary.
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundautism spectrum disorder (ASD) is a neurodevelopmental disorder affecting around 1 out of 68 children and its incidence shows an increasing tendency. There is currently no effective treatment for ASD. In autism research, the valproate (VPA)-induced autism rodent model is widely accepted. Our previous results showed that intraamygdaloid oxytocin (OT) has anxiolytic effects on rats showing autistic signs under the VPA-induced autism model.

methodsrats were stereotaxically implanted with guide cannulae bilaterally and received intraamygdaloid microinjections. In the present study, we investigated the possible role of intraamygdaloid OT and D2 dopamine (DA) receptors on reinforcement using VPA-treated rats in a conditioned place preference test. OT and/or an OT receptor antagonist or a D2 DA antagonist were microinjected into the central nucleus of the amygdala (CeA).

resultsvalproate-treated rats receiving 10 ng OT spent significantly longer time in the treatment quadrant during the test session of the conditioned place preference test. Prior treatment with an OT receptor antagonist or with a D2 DA receptor antagonist blocked the positive reinforcing effects of OT. The OT receptor antagonist or D2 DA antagonist in themselves did not influence the time rats spent in the treatment quadrant.

conclusionsOur results show that OT has positive reinforcing effects under the VPA-induced autism rodent model and these effects are OT receptor-specific. Our data also suggest that the DAergic system plays a role in the positive reinforcing effects of OT because the D2 DA receptor antagonist can block these actions.

Indexed as

amygdalaautismdopamineoxytocinplace preferencereinforcementvalproate

Identifiers

PMID36140411
PMCPMC9496370
OpenAlexW4296251816

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.