Evidence map›Paper›PMID 36140369›Full record

ReviewBiomedicines2022

Predicting Outcome in Patients with Brain Injury: Differences between Machine Learning versus Conventional Statistics.

Antonio Cerasa, Gennaro Tartarisco, Roberta Bruschetta, Irene Ciancarelli, Giovanni Morone, Rocco Salvatore Calabrò, Giovanni Pioggia, Paolo Tonin, Marco Iosa

Abstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  10. Use of machine learning algorithms to construct models of symptom burden cluster risk in breast cancer patients undergoing chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  12. Comparison of Machine Learning Models in Predicting Mental Health Sequelae Following Concussion in Youth.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Antonio CerasaInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy, 98164 Messina, Italy.
Gennaro TartariscoInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy, 98164 Messina, Italy.ORCID 0000-0001-9467-2024
Roberta BruschettaInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy, 98164 Messina, Italy.
Irene CiancarelliDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Giovanni MoroneDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0003-3602-4197
Rocco Salvatore CalabròIRCCS Centro Neurolesi "Bonino-Pulejo", 98123 Messina, Italy.ORCID 0000-0002-8566-3166
Giovanni PioggiaInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy, 98164 Messina, Italy.ORCID 0000-0002-8089-7449
Paolo ToninS. Anna Institute, 88900 Crotone, Italy.
Marco IosaIRCCS Centro Neurolesi "Bonino-Pulejo", 98123 Messina, Italy.ORCID 0000-0003-2434-3887

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Defining reliable tools for early prediction of outcome is the main target for physicians to guide care decisions in patients with brain injury. The application of machine learning (ML) is rapidly increasing in this field of study, but with a poor translation to clinical practice. This is basically dependent on the uncertainty about the advantages of this novel technique with respect to traditional approaches. In this review we address the main differences between ML techniques and traditional statistics (such as logistic regression, LR) applied for predicting outcome in patients with stroke and traumatic brain injury (TBI). Thirteen papers directly addressing the different performance among ML and LR methods were included in this review. Basically, ML algorithms do not outperform traditional regression approaches for outcome prediction in brain injury. Better performance of specific ML algorithms (such as Artificial neural networks) was mainly described in the stroke domain, but the high heterogeneity in features extracted from low-dimensional clinical data reduces the enthusiasm for applying this powerful method in clinical practice. To better capture and predict the dynamic changes in patients with brain injury during intensive care courses ML algorithms should be extended to high-dimensional data extracted from neuroimaging (structural and fMRI), EEG and genetics.

Indexed as

brain injurylinear regressionmachine learningprediction modelstroketraumatic brain injury

Identifiers

PMID36140369
PMCPMC9496389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.