ArticleBiomedicines2022
Stimulated Parotid Saliva Is a Better Method for Depression Prediction.
Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Predicting depression risk in middle-aged and elderly adults in China using CNN-BiLSTM-Attention mechanism and LSTM+SHAP framework.BMC psychiatry · 2025Article
- The association between urinary antibiotics levels and the risk of adolescent depression.Scientific reports · 2025Article
- A Bibliometric Analysis of Clinical Trials on Salivary Biomarkers for Mental Health (2003-2024).Cureus · 2024Review
- Neurodegeneration in Cognitive Impairment and Mood Disorders for Experimental, Clinical and Translational Neuropsychiatry.Biomedicines · 2024Article
- From CGRP to PACAP, VIP, and Beyond: Unraveling the Next Chapters in Migraine Treatment.Cells · 2023Review
- Athletic performance, sports experience, and exercise addiction: an association study onFrontiers in psychology · 2023Article
- Obtaining a Reliable Diagnostic Biomarker for Diabetes Mellitus by Standardizing Salivary Glucose Measurements.Biomolecules · 2022Article
- Artificial Intelligence in Spinal Imaging: Current Status and Future Directions.International journal of environmental research and public health · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSaliva cortisol is considered to be a biomarker of depression prediction. However, saliva collection methods can affect the saliva cortisol level.
objectiveThis study aims to determine the ideal saliva collection method and explore the application value of saliva cortisol in depression prediction.
methods30 depressed patients and 30 healthy controls were instructed to collect saliva samples in the morning with six collection methods. Simultaneous venous blood was collected. Enzyme-linked immunosorbent assay was used to determine the cortisol level. The 24-observerrated Hamilton depression rating scale (HAMD-24) was used to assess the severity of depression.
resultsThe significant differences in saliva cortisol levels depend on the saliva collection methods. The level of unstimulated whole saliva cortisol was most correlated with blood (r = 0.91). The stimulated parotid saliva cortisol can better predict depression. The area under the curve was 0.89. In addition, the saliva cortisol level of the depression patients was significantly higher than the healthy controls. The correlation between the cortisol level and the HAMD-24 score was highly significant. The higher the saliva cortisol level, the higher the HAMD-24 score.
conclusionsAll the above findings point to an exciting opportunity for non-invasive monitoring of cortisol through saliva.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.