Evidence map›Paper›PMID 36140307›Full record

ArticleBiomedicines2022

Novel 5-Nitrofuran-Tagged Imidazo-Fused Azines and Azoles Amenable by the Groebke-Blackburn-Bienaymé Multicomponent Reaction: Activity Profile against ESKAPE Pathogens and Mycobacteria.

Alexander Sapegin, Elizaveta Rogacheva, Lyudmila Kraeva, Maxim Gureev, Marine Dogonadze, Tatiana Vinogradova, Petr Yablonsky, Saeed Balalaie, Sergey V Baykov, Mikhail Krasavin

Abstract read
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In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. HPW-Catalyzed environmentally benign approach to imidazo[1,2-Beilstein journal of organic chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander SapeginInstitute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russia.
Elizaveta RogachevaPasteur Institute of Epidemiology and Microbiology, 14 Mira Street, Saint Petersburg 197101, Russia.
Lyudmila KraevaPasteur Institute of Epidemiology and Microbiology, 14 Mira Street, Saint Petersburg 197101, Russia.ORCID 0000-0002-9115-3250
Maxim GureevLaboratory of Chemoinformatics and Bioinformatics, Sechenov First Moscow State Medical University, Moscow 119435, Russia.ORCID 0000-0002-0385-922X
Marine DogonadzeSaint Petersburg Research Institute of Phthisiopulmonology, 2-4 Ligovsky Prospekt, Saint Petersburg 191036, Russia.
Tatiana VinogradovaSaint Petersburg Research Institute of Phthisiopulmonology, 2-4 Ligovsky Prospekt, Saint Petersburg 191036, Russia.
Petr YablonskySaint Petersburg Research Institute of Phthisiopulmonology, 2-4 Ligovsky Prospekt, Saint Petersburg 191036, Russia.
Saeed BalalaiePeptide Chemistry Research Center, K. N. Toosi University of Technology, Tehran 19697, Iran.ORCID 0000-0002-5764-0442
Sergey V BaykovInstitute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russia.ORCID 0000-0002-8912-5816
Mikhail KrasavinInstitute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russia.ORCID 0000-0002-0200-4772

Funding

Iranian National Science Foundation 98029575Russian Foundation for Basic Research 20-53-56002
6 · The paper itself

Abstract

A chemically diverse set of 13 5-nitrofuran-tagged heterocyclic compounds has been prepared via the Groebke-Blackburn-Bienaymé multicomponent reaction. The testing of these compounds against the so-called ESKAPE panel of pathogens identified an apparent lead compound-

Indexed as

5-nitrofurancarboxaldehydeantibacterial testingantimycobacterial activityESKAPE pathogensflexible dockingGroebke–Blackburn–Bienaymé multicomponent reactionimidazo-fused azines and azolesstrained ligand-protein interactions

Identifiers

PMID36140307
PMCPMC9496245

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.