Evidence map›Paper›PMID 36140302›Full record

ArticleBiomedicines2022

Evidence for an Intrathecal Immunoglobulin Synthesis by Kappa Free Light Chains in Neurological Patients with an Isolated Band in Isoelectric Focusing.

Bastian Weiss, Alexander Pichler, Anna Damulina, Arabella Buchmann, Sonja Hochmeister, Thomas Seifert-Held, Christian Enzinger, Juan-Jose Archelos, Michael Khalil

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bastian WeissDepartment of Neurology, Medical University of Graz, AT-8036 Graz, Austria.
Alexander PichlerDepartment of Neurology, Medical University of Graz, AT-8036 Graz, Austria.
Anna DamulinaDepartment of Neurology, Medical University of Graz, AT-8036 Graz, Austria.
Arabella BuchmannDepartment of Neurology, Medical University of Graz, AT-8036 Graz, Austria.ORCID 0000-0002-7381-2427
Sonja HochmeisterDepartment of Neurology, Medical University of Graz, AT-8036 Graz, Austria.
Thomas Seifert-HeldDepartment of Neurology, Medical University of Graz, AT-8036 Graz, Austria.
Christian EnzingerDepartment of Neurology, Medical University of Graz, AT-8036 Graz, Austria.
Juan-Jose ArchelosDepartment of Neurology, Medical University of Graz, AT-8036 Graz, Austria.
Michael KhalilDepartment of Neurology, Medical University of Graz, AT-8036 Graz, Austria.ORCID 0000-0002-5350-3328

Funding

Medical University of Graz Scholarship of the Medical University of Graz for scientific work (diploma thesis)
6 · The paper itself

Abstract

The gold standard for detecting intrathecal immunoglobulin synthesis is the determination of the oligoclonal band (OCB) in the cerebrospinal fluid (CSF) using isoelectric focusing (IEF). Controversy still exists regarding the significance of an isolated band in the CSF. A highly promising alternative method for the assessment of intrathecal inflammation is the quantification of kappa free light chains (k-FLC). Our aim was to evaluate the clinical significance of quantitative k-FLC in patients with an isolated band in the CSF. Using the Human Kappa Freelite Mx Kit on a turbidimetric Optilite

Indexed as

biomarkercentral nervous systemcerebrospinal fluidhumanimmunoglobulin kappa-chainsisoelectric focusingmultiple sclerosisneuroinflammatory diseases

Identifiers

PMID36140302
PMCPMC9496576

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.